Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | FPR2 | P25090 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.47 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.45 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | GMNN | O75496 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7306601 | 0.92 | ALDH1A1 (0.48) | KMT2AKDM4EALDH1A1HIF1AMEN1 | |
| SCHEMBL7274173 | 0.91 | KMT2A (0.51) | KMT2AKDM4EALDH1A1HIF1AGPR132 | |
| SCHEMBL7301518 | 0.86 | KMT2A (0.65) | KMT2AALDH1A1FPR2ITGA4ITGB7 | |
| SCHEMBL7274220 | 0.82 | ALDH1A1 (0.49) | KMT2AKDM4EALDH1A1HIF1AGPR132 | |
| SCHEMBL27303428 | 0.82 | ALDH1A1 (0.49) | KMT2AKDM4EALDH1A1HIF1AGPR132 | |
| SCHEMBL10534728 | 0.81 | FPR2 (0.53) | KMT2AALDH1A1FPR2ITGA4ITGB7 | |
| SCHEMBL7292751 | 0.79 | KMT2A (0.55) | KMT2AALDH1A1FPR2MEN1LMNA | |
| SCHEMBL9834187 | 0.77 | FPR2 (0.59) | KMT2AALDH1A1FPR2ITGA4ITGB7 | |
| SCHEMBL7301298 | 0.76 | KMT2A (0.48) | KMT2AALDH1A1FPR2ITGA4ITGB7 | |
| SCHEMBL7305790 | 0.75 | CA2 (0.55) | KMT2AKDM4EALDH1A1HIF1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5063208-A | Cardiovascular disorders, vision defects | ABBOTT LABORATORIES (US) | 1991-11-05 | — | — | US | disclosed |
| EP-0410260-A2 | Peptidyl aminodiol renin inhibitors | ABBOTT LABORATORIES (US) | 1991-01-30 | — | — | EP | disclosed |