Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 4/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | CNR1 | P21554 | 5/20 | 0.49 |
| ▸ | PLK1 | P53350 | 3/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4294889 | 0.91 | HTR4 (0.61) | HTR4CYP1A2CYP2C9ALOX15NFKB1 | |
| SCHEMBL7305753 | 0.87 | CNR1 (0.52) | HTR4CYP1A2CYP2C9ALOX15NFKB1 | |
| SCHEMBL7305923 | 0.87 | CNR1 (0.50) | HTR4CYP1A2CYP2C9ALOX15NFKB1 | |
| SCHEMBL7331887 | 0.82 | HRH2 (0.54) | CNR1PLK1CNR2 | |
| SCHEMBL9344560 | 0.82 | CNR1 (0.62) | CNR1PLK1CNR2 | |
| SCHEMBL7308948 | 0.80 | HTR4 (0.49) | HTR4CYP1A2CYP2C9ALOX15NFKB1 | |
| SCHEMBL9704182 | 0.79 | HTR4 (0.63) | HTR4CYP1A2CYP2C9ALOX15NFKB1 | |
| SCHEMBL7291968 | 0.79 | CNR1 (0.62) | NPSR1CNR1PLK1CNR2 | |
| SCHEMBL7300816 | 0.77 | HTR4 (0.54) | HTR4CYP1A2CYP2C9ALOX15NFKB1 | |
| SCHEMBL24437217 | 0.77 | CNR1 (0.66) | NPSR1CNR1PLK1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501322-B1 | 3-Piperidinylmethylcarboxylate substituted indoles | GLAXO GROUP LTD (GB) | 1996-09-04 | — | — | EP | claimed |