Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 5/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | CNR2 | P34972 | 6/20 | 0.48 |
| ▸ | CNR1 | P21554 | 5/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 2/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7301718 | 0.91 | HTR4 (0.62) | HTR4CYP2C9CYP1A2ALOX15NFKB1 | |
| SCHEMBL7308948 | 0.89 | HTR4 (0.49) | HTR4CYP2C9CYP1A2ALOX15NFKB1 | |
| SCHEMBL7310095 | 0.83 | CNR2 (0.47) | HTR4CYP2C9CYP1A2ALOX15NFKB1 | |
| SCHEMBL7305753 | 0.79 | CNR1 (0.52) | HTR4CYP2C9CYP1A2ALOX15NFKB1 | |
| SCHEMBL9704182 | 0.78 | HTR4 (0.63) | HTR4CYP2C9CYP1A2ALOX15NFKB1 | |
| SCHEMBL7305923 | 0.78 | CNR1 (0.50) | HTR4CYP2C9CYP1A2ALOX15NFKB1 | |
| SCHEMBL9543051 | 0.76 | CNR2 (0.52) | CNR2CNR1HRH2 | |
| SCHEMBL1502039 | 0.76 | HTR4 (1.00) | HTR4CYP2C9CYP1A2ALOX15NFKB1 | |
| SCHEMBL29397805 | 0.76 | HTR4 (1.00) | HTR4CYP2C9CYP1A2ALOX15NFKB1 | |
| SCHEMBL4294891 | 0.75 | HTR4 (0.55) | HTR4CYP2C9CYP1A2ALOX15NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992014727-A1 | 3-PIPERIDINYLMETHYLCARBOXYLATE SUBSTITUTED INDOLES | GLAXO GROUP LIMITED (GB) | 1992-09-03 | — | — | WO | claimed |
| US-8829028-B2 | 5-HT4 receptor antagonists for the treatment of heart failure | SERODUS AS (NO) | 2014-09-09 | — | — | US | disclosed |
| US-20090169545-A1 | 5-HT4 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF HEART FAILURE | SERODUS AS (NO) | 2009-07-02 | — | — | US | disclosed |
| US-20060094715-A1 | 5-Ht4 receptor antagonists for the treatment of heart failure | SERODUS AS (NO) | 2006-05-04 | — | — | US | disclosed |