Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.42 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.42 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CTSG | P08311 | 1/20 | 0.38 |
| ▸ | CMA1 | P23946 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7312132 | 0.95 | CTSG (0.43) | ALDH1A1POLBPSMB5PSMB1PSMB2 | |
| SCHEMBL7436642 | 0.88 | ALDH1A1 (0.42) | ALDH1A1POLBPSMB5PSMB1PSMB2 | |
| SCHEMBL7444403 | 0.87 | BCHE (0.42) | ALDH1A1POLBPSMB5PSMB1PSMB2 | |
| SCHEMBL7300553 | 0.86 | PSMB5 (0.51) | ALDH1A1POLBPSMB5PSMB1PSMB2 | |
| SCHEMBL7301741 | 0.86 | PSMB5 (0.47) | PSMB5PSMB1PSMB2 | |
| SCHEMBL7301731 | 0.86 | PSMB5 (0.47) | PSMB5PSMB1PSMB2 | |
| SCHEMBL7301724 | 0.86 | PSMB5 (0.47) | PSMB5PSMB1PSMB2 | |
| SCHEMBL7304423 | 0.85 | PSMB1 (0.48) | PSMB5PSMB1PSMB2 | |
| SCHEMBL7312640 | 0.85 | PSMB1 (0.44) | ALDH1A1POLBPSMB5PSMB1PSMB2 | |
| SCHEMBL7307063 | 0.85 | PSMB1 (0.48) | PSMB5PSMB1PSMB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525420-B1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | MITSUBISHI CHEM CORP (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5639783-A | POTENT PROTEASE INHIBITOR FOR TREATING MUSCULAR, NERVOUS SYSTEM DISEASES | MITSUBISHI CHEMICAL CORPORATION (JP) | 1997-06-17 | — | — | US | disclosed |
| EP-0525420-A1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | Mitsubishi Chemical Corporation (JP) | 1993-02-03 | — | — | EP | disclosed |