Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL491027 | 0.84 | LMNA (0.52) | ALDH1A1TSHRMAPK1TDP1L3MBTL1 | |
| SCHEMBL2673394 | 0.83 | ALDH1A1 (0.50) | ALDH1A1TSHRTDP1EPHX2SMN1; SMN2 | |
| SCHEMBL11847066 | 0.80 | POLB (0.42) | ALDH1A1TSHRL3MBTL1EPHX2SMN1; SMN2 | |
| SCHEMBL31075841 | 0.79 | NLRP3 (0.47) | ALDH1A1MAPK1SMN1; SMN2KMT2ANLRP3 | |
| SCHEMBL19502670 | 0.78 | MMP8 (0.54) | ALDH1A1TSHRTDP1SMN1; SMN2MMP8 | |
| SCHEMBL15391734 | 0.78 | MEN1 (0.45) | ALDH1A1TSHRMAPK1TDP1L3MBTL1 | |
| SCHEMBL7293339 | 0.77 | CYP4F2 (0.56) | ALDH1A1SMN1; SMN2NLRP3MAPTGAA | |
| SCHEMBL3344661 | 0.77 | EPHX2 (0.47) | ALDH1A1TSHRTDP1EPHX2MMP8 | |
| SCHEMBL490730 | 0.77 | ALDH1A1 (0.48) | ALDH1A1TSHRTDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL10978584 | 0.76 | GABRA1 (0.41) | ALDH1A1L3MBTL1SMN1; SMN2KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5444083-A | DOPAMINE AGONIST FOR TREATING OR PREVENTION OF HYPERTENSION OR HEART FAILURE | EISAI CO., LTD. (JP) | 1995-08-22 | — | — | US | disclosed |
| EP-0381235-B1 | PYRROLIDINE COMPOUND AND PHARMACEUTICAL USE | Eisai Co., Ltd. (JP) | 1993-07-28 | — | — | EP | disclosed |
| CN-1044652-A | Pyrrolidine compound and its pharmaceutical use | EISAI CO LTD (JP) | 1990-08-15 | — | — | CN | disclosed |
| EP-0381235-A2 | Pyrrolidine compound and pharmaceutical use | Eisai Co., Ltd. (JP) | 1990-08-08 | — | — | EP | disclosed |