SCHEMBL730223

SCHEMBL730223

COC(=O)CC(NC[Si](OC)(OC)OC)C(=O)OC

nearest known ligand 0.35

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA9 Q16790 1/20 0.33
TSHR P16473 3/20 0.32
HSD17B10 Q99714 1/20 0.30
MGAM O43451 1/20 0.30
GAA P10253 1/20 0.30
SI P14410 1/20 0.30
MGAM2 Q2M2H8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL728588 0.89 MAPT (0.32) CA12CA1CA2CA9
SCHEMBL730268 0.89 CA12 (0.30) CA12CA1CA2CA9
SCHEMBL730349 0.85 CA12 (0.32) CA12CA1CA2CA9MGAM
SCHEMBL728627 0.81 L3MBTL1 (0.44) TSHRHSD17B10MGAMGAASI
SCHEMBL2020702 0.80 CA12 (0.31) CA12CA1CA2CA9TSHR
SCHEMBL4199536 0.80 CA12 (0.31) CA12CA1CA2CA9TSHR
SCHEMBL20022609 0.78 TSHR (0.42) CA12CA1CA2CA9TSHR
SCHEMBL13921451 0.77 CA1 (0.39) CA12CA1CA2CA9TSHR
SCHEMBL28054767 0.77 CA1 (0.39) CA12CA1CA2CA9TSHR
SCHEMBL729753 0.77 NPSR1 (0.37) TSHRHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102361901-B Moisture-curable silylated polymer possessing improved storage stability MOMENTIVE PERFORMANCE MAT INC 2014-06-11 CN claimed
EP-2393861-B1 MOISTURE-CURABLE SILYLATED POLYMER POSSESSING IMPROVED STORAGE STABILITY MOMENTIVE PERFORMANCE MAT INC (US) 2013-10-23 EP claimed
US-8138297-B2 Moisture-curable silylated polymer possessing improved storage stability MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2012-03-20 US claimed
US-20100204384-A1 Moisture-curable silylated polymer possessing improved storage stability MOMENTIVE PERFORMANCE MATERIALS INC. 2010-08-12 US claimed
CN-102361901-B Moisture-curable silylated polymer possessing improved storage stability MOMENTIVE PERFORMANCE MAT INC 2014-06-11 CN disclosed
EP-2393861-B1 MOISTURE-CURABLE SILYLATED POLYMER POSSESSING IMPROVED STORAGE STABILITY MOMENTIVE PERFORMANCE MAT INC (US) 2013-10-23 EP disclosed
US-8138297-B2 Moisture-curable silylated polymer possessing improved storage stability MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2012-03-20 US disclosed
US-20100204384-A1 Moisture-curable silylated polymer possessing improved storage stability MOMENTIVE PERFORMANCE MATERIALS INC. 2010-08-12 US disclosed