Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 7/20 | 0.48 |
| ▸ | PPARA | Q07869 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043400 | 0.81 | PSMB5 (0.56) | PPARGPPARAKMT2AALDH1A1CYP2D6 | |
| SCHEMBL28530456 | 0.81 | LMNA (0.53) | PPARGPPARALMNAHPGDKMT2A | |
| SCHEMBL4043403 | 0.81 | PSMB5 (0.56) | PPARGPPARAKMT2AALDH1A1CYP2D6 | |
| SCHEMBL9800442 | 0.79 | FAAH (0.50) | PPARGPPARALMNAHPGDKMT2A | |
| SCHEMBL7304728 | 0.79 | FAAH (0.50) | PPARGPPARALMNAHPGDKMT2A | |
| SCHEMBL13518976 | 0.77 | LMNA (0.56) | PPARGPPARALMNAKMT2ACYP2D6 | |
| SCHEMBL6486378 | 0.77 | PPARG (0.59) | PPARGPPARA | |
| SCHEMBL8086810 | 0.75 | LAP3 (0.41) | PPARGPPARAALDH1A1 | |
| SCHEMBL9760951 | 0.75 | IDO1 (0.52) | LMNAKMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8330922 | 0.75 | PPARG (0.50) | PPARGPPARALMNAMMP8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0520336-A2 | Aldehyde derivatives and their use as calpain inhibitors | FUJIREBIO Inc. (JP) | 1992-12-30 | — | — | EP | disclosed |