Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303500 | 0.95 | POLB (0.53) | IGF1RHTR1AKDM4EMAPTSIRT6 | |
| SCHEMBL10036175 | 0.81 | MAPT (0.53) | MAPTSIRT6ALDH1A1MEN1KMT2A | |
| SCHEMBL9451699 | 0.79 | SIRT6 (0.51) | MAPTSIRT6ALDH1A1MEN1KMT2A | |
| SCHEMBL3440216 | 0.78 | MAPT (0.59) | MAPTSIRT6ALDH1A1MEN1KMT2A | |
| SCHEMBL7319744 | 0.77 | KDM4E (0.48) | KDM4EMEN1KMT2ALMNA | |
| SCHEMBL9451638 | 0.77 | SIGMAR1 (0.51) | MAPTSIRT6ALDH1A1MEN1KMT2A | |
| SCHEMBL9309161 | 0.77 | KDM4E (0.47) | IGF1RHTR1AKDM4EMAPTMEN1 | |
| SCHEMBL15372693 | 0.76 | MAPT (0.54) | MAPTSIRT6ALDH1A1MEN1KMT2A | |
| SCHEMBL16580726 | 0.76 | SIRT6 (0.56) | MAPTSIRT6ALDH1A1MEN1KMT2A | |
| SCHEMBL14167563 | 0.75 | MAPT (0.59) | MAPTSIRT6ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0503411-B1 | Substituted N-phenylpiperidines and medicaments thereof | BASF AG (DE) | 1995-11-29 | — | — | EP | disclosed |
| US-5296485-A | Substituted N-phenylpiperidines and drugs therefrom | BASF AKTIENGESELLSCHAFT (DE) | 1994-03-22 | — | — | US | disclosed |
| EP-0503411-A1 | Substituted N-phenylpiperidines and medicaments thereof | BASF Aktiengesellschaft (DE) | 1992-09-16 | — | — | EP | disclosed |