Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 9/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7302491 | 0.95 | IGF1R (0.53) | POLBIGF1RMEN1KMT2AMAPT | |
| SCHEMBL9309161 | 0.84 | KDM4E (0.47) | IGF1RMEN1KMT2AMAPTLMNA | |
| SCHEMBL9451695 | 0.81 | POLB (0.59) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL10036175 | 0.76 | MAPT (0.53) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL9451699 | 0.75 | SIRT6 (0.51) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL15372693 | 0.74 | MAPT (0.54) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL3440216 | 0.74 | MAPT (0.59) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL7319744 | 0.73 | KDM4E (0.48) | MEN1KMT2ALMNAKDM4E | |
| SCHEMBL9451638 | 0.73 | SIGMAR1 (0.51) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL12005574 | 0.72 | POLB (1.00) | POLBMEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0503411-B1 | Substituted N-phenylpiperidines and medicaments thereof | BASF AG (DE) | 1995-11-29 | — | — | EP | disclosed |
| US-5296485-A | Substituted N-phenylpiperidines and drugs therefrom | BASF AKTIENGESELLSCHAFT (DE) | 1994-03-22 | — | — | US | disclosed |