Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 9/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4939421 | 0.86 | SLC6A3 (0.77) | SLC6A3SLC6A2HSP90AA1SLC6A4 | |
| SCHEMBL11665417 | 0.84 | SLC6A3 (0.75) | SLC6A3SLC6A2HSP90AA1SLC6A4ALDH1A1 | |
| SCHEMBL27513426 | 0.83 | SLC6A2 (0.50) | OPRD1SLC6A3SLC6A2HSP90AA1OPRM1 | |
| SCHEMBL3401494 | 0.82 | SLC6A2 (0.49) | OPRD1SLC6A3SLC6A2HSP90AA1OPRM1 | |
| SCHEMBL501353 | 0.82 | HSD17B10 (0.61) | SLC6A3SLC6A2HSP90AA1DRD3SLC6A4 | |
| SCHEMBL4313458 | 0.81 | HSP90AA1 (0.59) | SLC6A3SLC6A2HSP90AA1DRD3SLC6A4 | |
| SCHEMBL4869220 | 0.80 | OPRD1 (0.53) | OPRD1SLC6A3SLC6A2OPRM1SIGMAR1 | |
| SCHEMBL28598873 | 0.79 | SIGMAR1 (0.56) | OPRD1SLC6A3SLC6A2OPRM1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL27492948 | 0.78 | OPRD1 (0.52) | OPRD1SLC6A3SLC6A2OPRM1SIGMAR1 | |
| SCHEMBL1494478 | 0.77 | SIGMAR1 (0.43) | OPRD1SLC6A3SLC6A2OPRM1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-5238934-A | — | — | None | — | — | JP | disclosed |
| EP-0538897-B1 | The use of BMY 14802 in the treatment of anxiety in benzodiazepine-withdrawn patients | BRISTOL MYERS SQUIBB CO (US) | 1997-03-26 | — | — | EP | disclosed |
| US-5278164-A | Treatment of anxiety in benzodiazepine-withdrawn patients | BRISTOL-MYERS SQUIBB CO. (US) | 1994-01-11 | — | — | US | disclosed |
| JP-H05238934-A | ANTIDEPRESSANT | BRISTOL MYERS SQUIBB CO | 1993-09-17 | — | — | JP | disclosed |
| EP-0538897-A1 | The use of BMY 14802 in the treatment of anxiety in benzodiazepine-withdrawn patients | Bristol-Myers Squibb Company (US) | 1993-04-28 | — | — | EP | disclosed |
| US-5055470-A | METHOD OF TREATMENT OF ISCHEMIA IN BRAIN | BRISTOL-MYERS SQUIBB CO. (US) | 1991-10-08 | — | — | US | disclosed |
| US-4994460-A | Treatment or prevention of disorders resulting from central nervous system anoxia | BRISTOL-MYERS SQUIBB CO. (US) | 1991-02-19 | — | — | US | disclosed |
| EP-0410114-A2 | Use of 4-[4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl]-1-(4-fluorophenyl)-butanol in pharmaceutical compositions for the treatment of ischemia in brain | Bristol-Myers Squibb Company (US) | 1991-01-30 | — | — | EP | disclosed |
| EP-0400661-A1 | Agents for treatment of brain ischemia | Bristol-Myers Squibb Company (US) | 1990-12-05 | — | — | EP | disclosed |
| US-4605655-A | NEUROLEPTIC AGENTS; NO MOVEMENT DISORDER SIDE EFFECTS | BRISTOL-MYERS COMPANY (US) | 1986-08-12 | — | — | US | disclosed |
| US-3933824-A | Piperazinobutyrophenone derivatives | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1976-01-20 | — | — | US | disclosed |