Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.49 |
| ▸ | SLC16A1 | P53985 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28860292 | 0.98 | ALDH1A1 (0.63) | ALDH1A1LMNAHIF1AMEN1KMT2A | |
| SCHEMBL2498677 | 0.85 | MEN1 (0.60) | ALDH1A1LMNAHIF1AMEN1KMT2A | |
| SCHEMBL27988319 | 0.85 | ALDH1A1 (0.49) | ALDH1A1LMNAHIF1AMEN1KMT2A | |
| SCHEMBL8344083 | 0.85 | ALDH1A1 (0.57) | ALDH1A1LMNAHIF1AMEN1KMT2A | |
| SCHEMBL13243994 | 0.85 | SIRT6 (0.63) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL12806668 | 0.85 | ALDH1A1 (0.61) | ALDH1A1LMNAHIF1AMEN1KMT2A | |
| SCHEMBL12856135 | 0.83 | ALDH1A1 (0.59) | ALDH1A1LMNAHIF1AMEN1KMT2A | |
| SCHEMBL361649 | 0.83 | ADRB1 (0.61) | LMNAMAPTHTR7 | |
| SCHEMBL15928735 | 0.83 | S100B (0.56) | ALDH1A1LMNAHIF1AMEN1KMT2A | |
| SCHEMBL4147257 | 0.83 | ALDH1A1 (0.47) | ALDH1A1LMNAHIF1AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |
| EP-0381235-A2 | Pyrrolidine compound and pharmaceutical use | Eisai Co., Ltd. (JP) | 1990-08-08 | — | — | EP | disclosed |