Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR6 | O00574 | 1/20 | 0.55 |
| ▸ | VCP | P55072 | 1/20 | 0.47 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.46 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.45 |
| ▸ | HTR3B | O95264 | 2/20 | 0.45 |
| ▸ | HTR3A | P46098 | 2/20 | 0.45 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.45 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.44 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23251146 | 0.82 | HTR3A (0.52) | CXCR6HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL8102814 | 0.81 | VCP (0.50) | CXCR6VCPHTR3EHTR3BHTR3A | |
| SCHEMBL9876385 | 0.76 | HTR3A (0.50) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7448002 | 0.76 | HRH3 (0.48) | VCP | |
| SCHEMBL34468335 | 0.75 | KDR (0.52) | NLRP3GID4GSK3B | |
| SCHEMBL7296680 | 0.74 | HRH3 (0.52) | CXCR6VCPHTR3EHTR3BHTR3A | |
| SCHEMBL18876541 | 0.74 | NLRP3 (0.56) | NLRP3GSK3B | |
| SCHEMBL17327742 | 0.72 | NLRP3 (0.60) | NLRP3GSK3B | |
| Maleic Acid SCHEMBL7333919 | 0.72 | KDM4E (0.49) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8947376 | 0.70 | HTR3A (0.64) | HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0385722-B1 | Tricyclic lactam derivatives and pharmaceutical compositions containing them | GLAXO GROUP LTD (GB) | 1995-04-19 | — | — | EP | disclosed |