Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.47 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | VCP | P55072 | 1/20 | 0.44 |
| ▸ | CASR | P41180 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8102814 | 0.95 | VCP (0.50) | HRH3CHRNA7SSTR3HRH4VCP | |
| SCHEMBL7296680 | 0.88 | HRH3 (0.52) | HRH3CHRNA7HRH4VCPDRD2 | |
| SCHEMBL2278489 | 0.82 | SSTR3 (0.54) | HRH3CHRNA7SSTR3VCPCASR | |
| SCHEMBL8110562 | 0.81 | RAB9A (0.40) | CHRNA7VCP | |
| SCHEMBL8111998 | 0.80 | CHRM1 (0.39) | VCPDRD4DRD3 | |
| SCHEMBL22604095 | 0.78 | SSTR3 (0.57) | HRH3SSTR3 | |
| SCHEMBL8112708 | 0.77 | MTNR1A (0.40) | CHRNA7VCP | |
| SCHEMBL8102563 | 0.76 | MTNR1A (0.41) | CHRNA7HRH4VCP | |
| SCHEMBL7303201 | 0.76 | CXCR6 (0.55) | VCP | |
| SCHEMBL22584092 | 0.74 | SSTR3 (0.73) | HRH3CHRNA7SSTR3CASR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711299-B1 | AZABICYCLOALKYL DERIVATIVES OF IMIDAZO(1,5-a)INDOL-3-ONE AS 5HT 3 ANTAGONISTS | PHARMACIA & UPJOHN SPA (IT) | 2000-01-05 | — | — | EP | disclosed |
| US-5637596-A | REACTING AMINOMETHYLINDOLE DERIVATIVE WITH A CARBONYL CONTAINING CYCLIZING AGENT; 5-HT3 RECEPTOR ATAGONIST; USEFUL FOR TREATING ANXIETY, PSYCHOSIS, GUT MOTILITY DISORDER, EMESIS, MIGRAINE AND DRUG ADDICTION | PHARMACIA S.P.A. (IT) | 1997-06-10 | — | — | US | disclosed |
| EP-0711299-A1 | AZABICYCLOALKYL DERIVATIVES OF IMIDAZO(1,5-a)INDOL-3-ONE AS 5HT 3 ANTAGONISTS | PHARMACIA & UPJOHN S.p.A. (IT) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995032209-A1 | AZABICYCLOALKYL DERIVATIVES OF IMIDAZO(1,5-a)INDOL-3-ONE AS 5HT3 ANTAGONISTS | PHARMACIA S.P.A. (IT) | 1995-11-30 | — | — | WO | disclosed |