Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | REN | P00797 | 5/20 | 0.39 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.38 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.38 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7302930 | 0.91 | PSMB1 (0.36) | ALDH1A1HPGDSMN1; SMN2CTSKCTSS | |
| SCHEMBL7305805 | 0.90 | MGLL (0.38) | ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7438379 | 0.90 | CYP1A2 (0.39) | ALDH1A1HPGDSMN1; SMN2PSMB5PSMB1 | |
| SCHEMBL8680990 | 0.89 | ALDH1A1 (0.40) | ALDH1A1HPGDSMN1; SMN2CTSKCTSS | |
| SCHEMBL7437245 | 0.89 | CAPN1 (0.46) | CTSKCTSSREN | |
| SCHEMBL7437237 | 0.89 | CAPN1 (0.46) | CTSKCTSSREN | |
| SCHEMBL7303213 | 0.88 | PSMB1 (0.41) | ALDH1A1CTSKPSMB5PSMB1PSMB2 | |
| SCHEMBL7307063 | 0.88 | PSMB1 (0.48) | CTSKCTSSPSMB5PSMB1PSMB2 | |
| SCHEMBL7312640 | 0.88 | PSMB1 (0.44) | ALDH1A1CTSKCTSSPSMB5PSMB1 | |
| SCHEMBL7304423 | 0.88 | PSMB1 (0.48) | CTSKCTSSPSMB5PSMB1PSMB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525420-B1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | MITSUBISHI CHEM CORP (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5834508-A | PROTEASE ENZYME INHIBITORS; MUSCLE DISORDERS | MITSUBISHI CHEMICAL CORPORATION (JP) | 1998-11-10 | — | — | US | disclosed |
| US-5639783-A | POTENT PROTEASE INHIBITOR FOR TREATING MUSCULAR, NERVOUS SYSTEM DISEASES | MITSUBISHI CHEMICAL CORPORATION (JP) | 1997-06-17 | — | — | US | disclosed |