Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 12/20 | 0.49 |
| ▸ | METAP1 | P53582 | 7/20 | 0.49 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | REN | P00797 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10520251 | 0.87 | REN (0.41) | METAP2METAP1CTSSCTSKREN | |
| SCHEMBL7328407 | 0.84 | METAP2 (0.55) | METAP2METAP1REN | |
| SCHEMBL8175196 | 0.84 | METAP2 (0.55) | METAP2METAP1REN | |
| SCHEMBL20244849 | 0.84 | CTSK (0.45) | METAP2CTSSCTSK | |
| SCHEMBL22090642 | 0.84 | CTSK (0.45) | METAP2CTSSCTSK | |
| Hydrochloric Acid SCHEMBL9514516 | 0.83 | METAP2 (0.53) | METAP2METAP1REN | |
| Hydrochloric Acid SCHEMBL9514519 | 0.83 | METAP2 (0.53) | METAP2METAP1REN | |
| SCHEMBL7359911 | 0.82 | METAP2 (0.57) | METAP2METAP1CTSSCTSKREN | |
| SCHEMBL7301464 | 0.82 | METAP2 (0.40) | METAP2METAP1CTSSCTSKREN | |
| SCHEMBL28764792 | 0.82 | CTSK (0.43) | METAP2CTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5190922-A | Antiinflammatory | ABBOTT LABORATORIES (US) | 1993-03-02 | — | — | US | disclosed |
| WO-1992021361-A1 | TERMINALLY MODIFIED TRI-, TETRA- AND PENTAPEPTIDE ANAPHYLATOXIN RECEPTOR LIGANDS | ABBOTT LABORATORIES (US) | 1992-12-10 | — | — | WO | disclosed |
| US-5122610-A | Renin inhibitor intermediates | BAYER AKTIENGESELLSCHAFT (DE) | 1992-06-16 | — | — | US | disclosed |
| EP-0356796-A2 | Aminomethyl peptides, production process and their use as medicaments | BAYER AG (DE) | 1990-03-07 | — | — | EP | disclosed |