Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 9/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | NOS1 | P29475 | 1/20 | 0.63 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.63 |
| ▸ | LTA4H | P09960 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.59 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.59 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7296483 | 0.93 | TBXAS1 (0.86) | TBXAS1KDM4ENOS1CACNA1BKMT2A | |
| SCHEMBL8995313 | 0.85 | TBXAS1 (0.74) | TBXAS1KDM4EALDH1A1MAPK1NOS1 | |
| SCHEMBL8687327 | 0.85 | TBXAS1 (1.00) | TBXAS1KDM4EALDH1A1MAPK1NOS1 | |
| SCHEMBL7873899 | 0.84 | TBXAS1 (0.72) | TBXAS1KDM4ENOS1CACNA1BKMT2A | |
| Hydrochloric Acid SCHEMBL10751578 | 0.84 | TBXAS1 (0.97) | TBXAS1KDM4EALDH1A1MAPK1NOS1 | |
| Hydrochloric Acid SCHEMBL7875269 | 0.83 | TBXAS1 (0.70) | TBXAS1KDM4ENOS1CACNA1BKMT2A | |
| SCHEMBL24414559 | 0.83 | TBXAS1 (0.71) | TBXAS1KDM4EALDH1A1MAPK1LMNA | |
| SCHEMBL305632 | 0.81 | ALDH1A1 (0.72) | TBXAS1KDM4EALDH1A1MAPK1NOS1 | |
| SCHEMBL8690248 | 0.81 | KMT2A (0.83) | TBXAS1KDM4EALDH1A1MAPK1NOS1 | |
| SCHEMBL8684965 | 0.81 | MAPK1 (1.00) | TBXAS1KDM4EALDH1A1MAPK1NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5708171-A | HISTAMINE H3-RECEPTOR ANTAGONIST | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1998-01-13 | — | — | US | claimed |
| WO-1999002532-A2 | PARTIALLY HYDROGENATED POLYCYCLIC COMPOUNDS | NOVARTIS AG (CH) | 1999-01-21 | — | — | WO | disclosed |
| US-5708171-A | HISTAMINE H3-RECEPTOR ANTAGONIST | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1998-01-13 | — | — | US | disclosed |
| EP-0504574-B1 | 1,2,4-Oxadiazole derivatives having monoamine oxidase B enzyme-inhibitory activity and method for preparing same | WAKAMOTO PHARMA CO LTD (JP) | 1996-02-28 | — | — | EP | disclosed |
| US-5356916-A | Treating Parkinson*s disease | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1994-10-18 | — | — | US | disclosed |
| US-4636500-A | N-(phenoxyalkyl)imidazoles as selective inhibitors of the thromboxane synthetase enzyme and pharmaceutical compositions thereof | PFIZER INC. (US) | 1987-01-13 | — | — | US | disclosed |
| US-4602016-A | N-(phenoxyalkyl)imidazoles as selective inhibitors of the thromboxane synthetase enzyme and pharmaceutical compositions thereof | PFIZER INC. (US) | 1986-07-22 | — | — | US | disclosed |