Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PDE2A | O00408 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.40 |
| ▸ | PDE1A | P54750 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.39 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.33 |
| ▸ | P4HB | P07237 | 1/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303650 | 1.00 | PDE3B (0.48) | PDE3BPDE3ARAB9AKMT2AALDH1A1 | |
| SCHEMBL10667819 | 0.80 | PDE3B (0.46) | PDE3BPDE3ARAB9AKMT2AALDH1A1 | |
| SCHEMBL7293060 | 0.76 | PDE3B (0.54) | PDE3BPDE3AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL11006142 | 0.73 | PDE3B (0.52) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL11016051 | 0.71 | RAB9A (0.58) | PDE3BPDE3ARAB9AKMT2AALDH1A1 | |
| SCHEMBL11016050 | 0.71 | RAB9A (0.58) | PDE3BPDE3ARAB9AKMT2AALDH1A1 | |
| SCHEMBL7409893 | 0.70 | PDE3B (0.49) | PDE3BPDE3APOLBPDE2APDE1A | |
| SCHEMBL7425735 | 0.70 | PDE3B (0.52) | PDE3BPDE3AALDH1A1KDM4EHTT | |
| SCHEMBL10627611 | 0.69 | PDE3B (0.43) | PDE3BPDE3AALDH1A1KDM4EPDE2A | |
| SCHEMBL7296206 | 0.69 | MAOB (0.57) | RAB9AKMT2AALDH1A1NPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4599332-A | CARDIOTONIC, HYPOTENSIVE | WARNER-LAMBERT COMPANY (US) | 1986-07-08 | — | — | US | disclosed |
| EP-0145450-A2 | 6- [2-[4-(1H-imidazol-1-yl)phenyl]-alkylene and alkylenyl]-3(2H)-pyridazinones, the 4,5-dihydro- pyridazinone derivatives thereof, and a process for the preparation thereof | WARNER-LAMBERT COMPANY (US) | 1985-06-19 | — | — | EP | disclosed |