Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
| ▸ | NPY2R | P49146 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.41 |
| ▸ | PDE2A | O00408 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7325592 | 0.80 | HRH3 (0.67) | SMN1; SMN2HRH3LMNANPY1RNPY2R | |
| SCHEMBL7295674 | 0.79 | SMN1; SMN2 (0.50) | SMN1; SMN2HRH3LMNANPY1RNPY2R | |
| SCHEMBL10689941 | 0.75 | TDP1 (0.57) | SMN1; SMN2MAPTCA1CA2CA4 | |
| SCHEMBL4901340 | 0.74 | HRH3 (0.47) | SMN1; SMN2HRH3LMNANPY1RNPY2R | |
| SCHEMBL10679990 | 0.73 | MMP2 (0.55) | LMNAMAPTCA1CA2CA4 | |
| SCHEMBL9878387 | 0.72 | ALDH1A1 (0.45) | SMN1; SMN2HRH3LMNAPDE3BPDE3A | |
| SCHEMBL17261347 | 0.71 | TDP1 (0.59) | SMN1; SMN2MAPTCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL4764067 | 0.70 | ALDH1A1 (0.50) | SMN1; SMN2CA1CA2CA4CA9 | |
| SCHEMBL4903450 | 0.70 | PDE4B (0.47) | SMN1; SMN2HRH3LMNANPY1RNPY2R | |
| SCHEMBL10353452 | 0.69 | SMN1; SMN2 (0.81) | SMN1; SMN2HRH3LMNANPY1RNPY2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |