Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | NPY1R | P25929 | 1/20 | 0.65 |
| ▸ | NPY2R | P49146 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | PDE2A | O00408 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4901340 | 0.84 | HRH3 (0.47) | HRH3LMNANPY1RNPY2RMAPT | |
| SCHEMBL10258996 | 0.80 | HRH3 (1.00) | HRH3LMNANPY1RNPY2RMAPT | |
| SCHEMBL7303673 | 0.80 | SMN1; SMN2 (0.48) | HRH3LMNANPY1RNPY2RMAPT | |
| SCHEMBL12017607 | 0.79 | HRH3 (0.98) | HRH3LMNANPY1RNPY2RMAPT | |
| SCHEMBL1373314 | 0.79 | LMNA (0.80) | HRH3LMNANPY1RNPY2RMAPT | |
| SCHEMBL10967326 | 0.79 | LMNA (1.00) | HRH3LMNANPY1RNPY2RMAPT | |
| SCHEMBL4903450 | 0.78 | PDE4B (0.47) | HRH3LMNANPY1RNPY2RMAPT | |
| SCHEMBL7335953 | 0.78 | HRH3 (0.69) | HRH3MAPTRAB9ASMN1; SMN2HPGD | |
| SCHEMBL7306239 | 0.78 | LMNA (0.78) | HRH3LMNANPY1RNPY2RMAPT | |
| SCHEMBL10674350 | 0.77 | RAB9A (0.82) | HRH3MAPTRAB9ASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5204463-A | Substituted methoxyphenyl-4,5 dihydro-3(2H)-pridazinones having cardiotonic and beta blocking activities | GLAXO INC. (US) | 1993-04-20 | — | — | US | disclosed |
| US-5096904-A | Congestive heart failure | GLAXO INC. (US) | 1992-03-17 | — | — | US | disclosed |
| US-5053338-A | Hydrolysis of ester to obtain an optically enriched mixture of a phenol enantiomer | GLAXO INC. (US) | 1991-10-01 | — | — | US | disclosed |
| EP-0412814-A2 | Pyridazinones having cardiotonic and beta blocking activity | GLAXO WELLCOME INC. (US) | 1991-02-13 | — | — | EP | disclosed |