Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27871609 | 0.84 | ALDH1A1 (0.46) | ALDH1A1KEAP1TDP1KMT2AL3MBTL1 | |
| SCHEMBL7060693 | 0.83 | ALDH1A1 (0.52) | ALDH1A1KEAP1TDP1KMT2AL3MBTL1 | |
| SCHEMBL4976027 | 0.83 | CES1 (0.44) | ALDH1A1KMT2AL3MBTL1MEN1HDAC8 | |
| SCHEMBL7414176 | 0.82 | L3MBTL1 (0.49) | ALDH1A1L3MBTL1HTTCA12CA1 | |
| SCHEMBL3997663 | 0.81 | ALDH1A1 (0.53) | ALDH1A1KEAP1TDP1HTTFFAR1 | |
| SCHEMBL21805717 | 0.80 | L3MBTL1 (0.53) | L3MBTL1HTTSMN1; SMN2CTSSIDO1 | |
| SCHEMBL1380801 | 0.80 | TDP1 (0.61) | ALDH1A1KEAP1TDP1KMT2AL3MBTL1 | |
| SCHEMBL7299043 | 0.79 | MAPT (0.53) | ALDH1A1KEAP1TDP1KMT2AL3MBTL1 | |
| SCHEMBL7061341 | 0.78 | ALDH1A1 (0.46) | ALDH1A1KEAP1TDP1KMT2AL3MBTL1 | |
| SCHEMBL3291001 | 0.78 | KEAP1 (0.52) | ALDH1A1KEAP1TDP1HTTFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733642-B1 | Benzazepin-, benzoxazepin- and benzothiazepin-N-acetic acid-derivatives, their preparation and their pharmaceutical compositions | SOLVAY PHARM GMBH (DE) | 2000-11-29 | — | — | EP | disclosed |
| EP-0830863-B1 | Drugs for increasing gastrointestinal blood supply | SOLVAY PHARM GMBH (DE) | 2000-05-10 | — | — | EP | disclosed |
| US-5783573-A | Pharmaceuticals which promote gastrointestinal blood circulation | SOLVAY PHARMACEUTICALS GMBH (DE) | 1998-07-21 | — | — | US | disclosed |
| EP-0830863-A1 | Drugs for increasing gastrointestinal blood supply | Solvay Pharmaceuticals GmbH (DE) | 1998-03-25 | — | — | EP | disclosed |
| US-5679700-A | STROMELYSIN INHIBITOR | MERCK & CO., INC. (US) | 1997-10-21 | — | — | US | disclosed |
| US-5677297-A | ENZYME INHIBITOR FOR TREATING THE HEART FAILURE TO REDUCE THE CARDIAC PRESSURE, DIURETICS | SOLVAY PHARMACEUTICALS GMBH (DE) | 1997-10-14 | — | — | US | disclosed |
| EP-0733642-A1 | Benzazepin-, benzoxazepin- and benzothiazepin-N-acetic acid-derivatives, their preparation and their pharmaceutical compositions | Kali-Chemie Pharma GmbH (DE) | 1996-09-25 | — | — | EP | disclosed |
| US-5389610-A | For cardiovascular disorders | SCHERING CORPORATION (US) | 1995-02-14 | — | — | US | disclosed |
| WO-1993014112-A1 | SUBSTITUTED PHOSPHINIC ACID-CONTAINING PEPTIDYL DERIVATIVES AS ANTIDEGENERATIVE AGENTS | MERCK & CO., INC. (US) | 1993-07-22 | — | — | WO | disclosed |
| EP-0502075-A1 | CARBOXYALKYLCARBONYL AMINOACID ENDOPEPTIDASE INHIBITORS | SCHERING CORPORATION (US) | 1992-09-09 | — | — | EP | disclosed |
| WO-1991007386-A1 | CARBOXYALKYLCARBONYL AMINOACID ENDOPEPTIDASE INHIBITORS | SCHERING CORPORATION (US) | 1991-05-30 | — | — | WO | disclosed |
| US-4866087-A | HYPOTENSIVE AGENTS | MERCK & CO., INC. (US) | 1989-09-12 | — | — | US | disclosed |
| US-4402969-A | UREA ANALOGS OF DIPEPTIDES | MERCK & CO., INC. (US) | 1983-09-06 | — | — | US | disclosed |
| EP-0061684-A1 | Urea compounds as antihypertensives | MERCK & CO. INC. (US) | 1982-10-06 | — | — | EP | disclosed |