Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 12/20 | 0.42 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303989 | 0.88 | DHPS (0.47) | DHPSEDNRAMCL1 | |
| SCHEMBL7328712 | 0.86 | EDNRA (0.48) | DHPSEDNRA | |
| SCHEMBL7302684 | 0.85 | DHPS (0.38) | DHPSEDNRALMNARORCMAPT | |
| SCHEMBL7297143 | 0.85 | DHPS (0.42) | DHPSEDNRARORCMCL1 | |
| SCHEMBL7302917 | 0.85 | EDNRA (0.51) | DHPSEDNRA | |
| SCHEMBL7305832 | 0.85 | ALDH1A1 (0.44) | DHPSEDNRAALDH1A1MEN1MAPT | |
| SCHEMBL8322432 | 0.84 | LMNA (0.41) | DHPSEDNRACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7303288 | 0.84 | EDNRA (0.46) | DHPSEDNRACYP1A2LMNAMEN1 | |
| SCHEMBL7293765 | 0.83 | EDNRA (0.44) | DHPSEDNRAALDH1A1LMNAMEN1 | |
| SCHEMBL7300166 | 0.82 | DHPS (0.38) | DHPSEDNRARORCMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |