Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7309843 | 0.81 | FPR2 (0.67) | KMT2AMEN1CYP2C9CYP2C19RAB9A | |
| SCHEMBL7305276 | 0.79 | ELANE (0.56) | CYP3A4ALDH1A1TSHRLMNA | |
| SCHEMBL12348789 | 0.79 | RAB9A (0.65) | KMT2AMEN1RAB9ANPC1GAA | |
| SCHEMBL7304298 | 0.78 | MEN1 (0.46) | KMT2AMEN1CYP2C9CYP2C19RAB9A | |
| SCHEMBL12516497 | 0.77 | ERAP2 (0.57) | KMT2AMEN1ALDH1A1CTSBCTSK | |
| SCHEMBL7039657 | 0.76 | RAB9A (0.69) | KMT2AMEN1RAB9ANPC1GAA | |
| SCHEMBL20442278 | 0.76 | KMT2A (0.72) | KMT2AMEN1RAB9ANPC1GAA | |
| SCHEMBL21274443 | 0.76 | ERAP2 (0.56) | KMT2AMEN1ALDH1A1CTSBCTSK | |
| SCHEMBL21274440 | 0.76 | ERAP2 (0.56) | KMT2AMEN1ALDH1A1CTSBCTSK | |
| SCHEMBL22388846 | 0.75 | KMT2A (0.76) | KMT2AMEN1RAB9ANPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0494071-B1 | Trifluoromethylketone tripeptide derivatives | FUJISAWA PHARMACEUTICAL CO (JP) | 1997-04-16 | — | — | EP | disclosed |
| US-5430025-A | Elastase-inhibiting peptides bearing a C-terminal trifluoromethylketone moiety | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-07-04 | — | — | US | disclosed |
| US-5296591-A | Enzyme inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-03-22 | — | — | US | disclosed |
| EP-0494071-A2 | Trifluoromethylketone tripeptide derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-08 | — | — | EP | disclosed |