Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 8/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 3/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | MMP14 | P50281 | 2/20 | 0.41 |
| ▸ | MMP3 | P08254 | 2/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | MMP16 | P51512 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7311892 | 0.76 | MMP1 (0.45) | MMP1HTR2ASLC6A4ALDH1A1MEN1 | |
| SCHEMBL7450024 | 0.72 | HTR2A (0.47) | HTR2ASLC6A4ALDH1A1MEN1KMT2A | |
| SCHEMBL30307015 | 0.70 | TRPV4 (0.46) | HTR2ASLC6A4ALDH1A1MEN1KMT2A | |
| SCHEMBL7386055 | 0.70 | TRPV4 (0.46) | HTR2ASLC6A4ALDH1A1MEN1KMT2A | |
| SCHEMBL27464049 | 0.70 | MMP1 (0.43) | MMP1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL6823261 | 0.69 | MMP1 (0.59) | MMP1ALDH1A1SMN1; SMN2MMP2MMP13 | |
| SCHEMBL10865382 | 0.69 | PTGES2 (0.57) | HTR2ASLC6A4ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL7311896 | 0.69 | MMP1 (0.50) | MMP1HTR2AALDH1A1MMP2MMP9 | |
| SCHEMBL7506483 | 0.68 | GAA (0.48) | HTR2ASLC6A4ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL7513509 | 0.67 | MMP13 (0.72) | MMP1MMP2MMP13MMP14MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1177821-C | Matrix metalloprotease inhibitors | - | 2004-12-01 | — | — | CN | disclosed |
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| CN-1160045-A | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 1997-09-24 | — | — | CN | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |