Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 5/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | PNLIP | P16233 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7302768 | 0.86 | MAPT (0.45) | L3MBTL1TDP1MAPTHPGDLMNA | |
| SCHEMBL7311896 | 0.81 | MMP1 (0.50) | MMP1L3MBTL1TDP1MAPTHTR2A | |
| SCHEMBL7304538 | 0.76 | MMP1 (0.48) | MMP1L3MBTL1TDP1MAPTHTR2A | |
| SCHEMBL27464049 | 0.70 | MMP1 (0.43) | MMP1L3MBTL1MAPTLMNAMEN1 | |
| SCHEMBL15911145 | 0.68 | L3MBTL1 (0.63) | L3MBTL1TDP1MAPTHPGDLMNA | |
| SCHEMBL8183410 | 0.68 | L3MBTL1 (0.53) | L3MBTL1TDP1MAPTLMNAMEN1 | |
| SCHEMBL7298900 | 0.67 | MMP1 (0.48) | MMP1HTT | |
| SCHEMBL7617296 | 0.67 | MAPT (0.50) | L3MBTL1TDP1MAPTHPGDLMNA | |
| SCHEMBL7302773 | 0.66 | ALDH1A1 (0.45) | MMP1L3MBTL1MAPTLMNAHTR2A | |
| SCHEMBL16316797 | 0.66 | L3MBTL1 (0.56) | L3MBTL1TDP1MAPTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |