Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.35 |
| ▸ | SLC34A1 | Q06495 | 4/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7297002 | 0.79 | TDP1 (0.45) | KDM4EHSD11B1PDE10A | |
| SCHEMBL7299383 | 0.77 | ALDH1A1 (0.43) | KDM4EGRM5MAPK14 | |
| Suritozole SCHEMBL121081 | 0.75 | RXFP1 (0.43) | KDM4EHSD11B1 | |
| SCHEMBL24407519 | 0.75 | GAA (0.40) | KDM4EHTTGRM5P2RX7HSD11B1 | |
| SCHEMBL7435538 | 0.73 | GRM5 (0.38) | GRM5CYP3A4PGR | |
| SCHEMBL7302275 | 0.72 | ALDH1A1 (0.33) | KDM4EHTTHSD11B1PDE4BPDE4D | |
| SCHEMBL14077025 | 0.72 | HSD11B1 (0.50) | P2RX7HSD11B1DPP4MAPK14 | |
| SCHEMBL175252 | 0.71 | KDM4E (0.47) | KDM4EHTTGRM5HSD11B1DPP4 | |
| SCHEMBL26111723 | 0.70 | SCN4A (0.47) | GRM5DPP4F2RL3PDE10A | |
| SCHEMBL10304594 | 0.68 | PDE10A (0.43) | KDM4EHTTGRM5P2RX7DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0452926-B1 | 5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful as memory enhancers | MERRELL DOW PHARMA (US) | 1996-03-13 | — | — | EP | claimed |
| US-5331002-A | 5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful as memory enhancers | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-07-19 | — | — | US | claimed |
| US-5236942-A | 5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful in the treatment of Altzheimer's dementia | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-08-17 | — | — | US | claimed |
| US-5100906-A | 5-ARYL-4-ALKYL-3H-1,2,4-TRIAZOLE-3-THIONES USEFUL AS MEMORY ENHANCERS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-03-31 | — | — | US | claimed |
| EP-0452926-A2 | 5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful as memory enhancers | MERRELL PHARMACEUTICALS INC. (US) | 1991-10-23 | — | — | EP | claimed |
| US-4912095-A | 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones useful as antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-27 | — | — | US | claimed |
| US-4775688-A | 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and their use as antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-10-04 | — | — | US | claimed |
| US-4912095-A | 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones useful as antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-27 | — | — | US | disclosed |
| US-4775688-A | 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and their use as antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-10-04 | — | — | US | disclosed |
| EP-0221485-A1 | 5-Aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and their use as antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-05-13 | — | — | EP | disclosed |