Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7297002 | 0.82 | TDP1 (0.45) | ALDH1A1HSD11B1PDE10APDE2ATDP1 | |
| SCHEMBL7299383 | 0.73 | ALDH1A1 (0.43) | ALDH1A1MEN1KMT2AMAPTTDP1 | |
| SCHEMBL10473909 | 0.73 | HSD11B1 (0.43) | ALDH1A1MEN1KMT2AHSD11B1MAPT | |
| SCHEMBL7435538 | 0.72 | GRM5 (0.38) | ALDH1A1MAPTRAB9ACYP11B1CYP11B2 | |
| SCHEMBL7304540 | 0.72 | KDM4E (0.40) | HSD11B1PDE10APDE4BPDE4DF2RL3 | |
| SCHEMBL7485829 | 0.68 | LMNA (0.50) | ALDH1A1MEN1KMT2AMAPTRAB9A | |
| SCHEMBL15639816 | 0.67 | BRD4 (0.45) | MAPTPDE10APDE2A | |
| SCHEMBL9833680 | 0.67 | MEN1 (0.42) | ALDH1A1MEN1KMT2AMAPTTDP1 | |
| SCHEMBL10424759 | 0.67 | KDM4E (0.47) | ALDH1A1MEN1KMT2AMAPTRAB9A | |
| SCHEMBL175211 | 0.66 | PDE4B (0.40) | ALDH1A1MAPTRAB9APDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0452926-B1 | 5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful as memory enhancers | MERRELL DOW PHARMA (US) | 1996-03-13 | — | — | EP | claimed |
| US-5331002-A | 5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful as memory enhancers | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-07-19 | — | — | US | claimed |
| US-5236942-A | 5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful in the treatment of Altzheimer's dementia | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-08-17 | — | — | US | claimed |
| US-5100906-A | 5-ARYL-4-ALKYL-3H-1,2,4-TRIAZOLE-3-THIONES USEFUL AS MEMORY ENHANCERS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-03-31 | — | — | US | claimed |
| EP-0452926-A2 | 5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful as memory enhancers | MERRELL PHARMACEUTICALS INC. (US) | 1991-10-23 | — | — | EP | claimed |
| US-4912095-A | 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones useful as antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-27 | — | — | US | claimed |
| US-4775688-A | 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and their use as antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-10-04 | — | — | US | claimed |
| US-4912095-A | 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones useful as antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-27 | — | — | US | disclosed |
| US-4775688-A | 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and their use as antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-10-04 | — | — | US | disclosed |
| EP-0221485-A1 | 5-Aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and their use as antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-05-13 | — | — | EP | disclosed |