Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.33 |
| ▸ | TYMP | P19971 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7299383 | 0.81 | ALDH1A1 (0.43) | GRM5ALDH1A1APOBEC3GHSD17B10MAPT | |
| Suritozole SCHEMBL121081 | 0.79 | RXFP1 (0.43) | PTGS2ALDH1A1APOBEC3GCYP1A2HSD17B10 | |
| SCHEMBL7306147 | 0.77 | MAPT (0.50) | GRM5ALDH1A1APOBEC3GUSP2NOTUM | |
| SCHEMBL7485829 | 0.77 | LMNA (0.50) | GRM5ALDH1A1APOBEC3GCYP1A2CYP3A4 | |
| SCHEMBL7304540 | 0.73 | KDM4E (0.40) | GRM5CYP3A4PGR | |
| SCHEMBL7297002 | 0.72 | TDP1 (0.45) | ALDH1A1APOBEC3GHSD17B10 | |
| SCHEMBL7302275 | 0.72 | ALDH1A1 (0.33) | ALDH1A1RAB9AMAPTCYP11B1CYP11B2 | |
| SCHEMBL2311265 | 0.72 | ALDH1A1 (0.66) | ALDH1A1APOBEC3GHSD17B10MAPT | |
| SCHEMBL7306066 | 0.72 | KDM4E (0.45) | PTGS2ALDH1A1CYP1A2CYP3A4HSD17B10 | |
| SCHEMBL9833680 | 0.72 | MEN1 (0.42) | GRM5ALDH1A1HSD17B10MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4775688-A | 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and their use as antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-10-04 | — | — | US | claimed |
| US-4775688-A | 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and their use as antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-10-04 | — | — | US | disclosed |
| EP-0221485-A1 | 5-Aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and their use as antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-05-13 | — | — | EP | disclosed |