Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7302275 | 0.82 | ALDH1A1 (0.33) | TDP1HSD11B1ALDH1A1KDM4EPDE2A | |
| SCHEMBL7304540 | 0.79 | KDM4E (0.40) | HSD11B1KDM4EPDE10A | |
| SCHEMBL10470912 | 0.79 | HSD11B1 (0.59) | TDP1HSD11B1ALDH1A1KDM4EPOLB | |
| SCHEMBL7298467 | 0.76 | NR1H2 (0.48) | HSD11B1APOBEC3GRXFP1 | |
| SCHEMBL7299383 | 0.73 | ALDH1A1 (0.43) | TDP1ALDH1A1HSD17B10KDM4EAPOBEC3G | |
| SCHEMBL13201981 | 0.73 | ADRA1A (0.43) | TDP1HSD11B1ALDH1A1ALOX15HSD17B10 | |
| SCHEMBL7435538 | 0.72 | GRM5 (0.38) | ALDH1A1HSD17B10APOBEC3G | |
| SCHEMBL9222791 | 0.72 | ALDH1A1 (0.71) | TDP1ALDH1A1ALOX15HSD17B10KDM4E | |
| SCHEMBL10941820 | 0.71 | NPC1 (0.49) | HSD11B1ALDH1A1HSD17B10PDE2APDE10A | |
| SCHEMBL14077015 | 0.70 | HSD11B1 (0.58) | HSD11B1POLBPDE2APDE10ADCTPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0452926-B1 | 5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful as memory enhancers | MERRELL DOW PHARMA (US) | 1996-03-13 | — | — | EP | claimed |
| US-5331002-A | 5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful as memory enhancers | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-07-19 | — | — | US | claimed |
| US-5236942-A | 5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful in the treatment of Altzheimer's dementia | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-08-17 | — | — | US | claimed |
| US-5100906-A | 5-ARYL-4-ALKYL-3H-1,2,4-TRIAZOLE-3-THIONES USEFUL AS MEMORY ENHANCERS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-03-31 | — | — | US | claimed |
| EP-0452926-A2 | 5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful as memory enhancers | MERRELL PHARMACEUTICALS INC. (US) | 1991-10-23 | — | — | EP | claimed |
| US-4912095-A | 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones useful as antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-27 | — | — | US | claimed |
| US-4775688-A | 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and their use as antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-10-04 | — | — | US | claimed |
| US-4912095-A | 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones useful as antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-27 | — | — | US | disclosed |
| US-4775688-A | 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and their use as antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-10-04 | — | — | US | disclosed |
| EP-0280867-A1 | Process for the preparation of 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-09-07 | — | — | EP | disclosed |
| EP-0221485-A1 | 5-Aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and their use as antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-05-13 | — | — | EP | disclosed |