Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.51 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7300251 | 0.88 | KMT2A (0.53) | LMNAKMT2AMAPTTSHR | |
| SCHEMBL8157305 | 0.80 | GPR132 (0.57) | KMT2AALDH1A1MAPTGPR132NAALAD2 | |
| SCHEMBL7280357 | 0.79 | LMNA (0.51) | LMNAKMT2AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL17117301 | 0.78 | EPHX2 (0.61) | KMT2AL3MBTL1 | |
| SCHEMBL30195922 | 0.78 | NAALAD2 (0.68) | LMNAKMT2AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL6121330 | 0.78 | LMNA (0.74) | LMNAKMT2AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL9557811 | 0.77 | GPR132 (0.54) | KMT2AGPR132 | |
| SCHEMBL2843465 | 0.76 | SMN1; SMN2 (0.58) | LMNAALDH1A1 | |
| SCHEMBL7301528 | 0.75 | KMT2A (0.87) | LMNAKMT2AALDH1A1TSHR | |
| SCHEMBL7274173 | 0.75 | KMT2A (0.51) | KMT2AALDH1A1MAPTGPR132TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5063208-A | Cardiovascular disorders, vision defects | ABBOTT LABORATORIES (US) | 1991-11-05 | — | — | US | disclosed |
| EP-0410260-A2 | Peptidyl aminodiol renin inhibitors | ABBOTT LABORATORIES (US) | 1991-01-30 | — | — | EP | disclosed |