Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 12/20 | 0.45 |
| ▸ | MMP1 | P03956 | 10/20 | 0.45 |
| ▸ | MMP9 | P14780 | 10/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 10/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 6/20 | 0.44 |
| ▸ | MMP14 | P50281 | 5/20 | 0.44 |
| ▸ | MMP3 | P08254 | 5/20 | 0.44 |
| ▸ | MMP8 | P22894 | 4/20 | 0.44 |
| ▸ | MMP7 | P09237 | 3/20 | 0.44 |
| ▸ | MMP10 | P09238 | 2/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7309706 | 0.89 | MMP13 (0.57) | MMP13MMP1MMP9ADAM17ALDH1A1 | |
| SCHEMBL7309299 | 0.82 | MMP1 (0.46) | MMP13MMP1MMP9ADAM17ALDH1A1 | |
| SCHEMBL7310855 | 0.82 | MMP13 (0.56) | MMP13MMP1MMP9ADAM17ALDH1A1 | |
| SCHEMBL7304591 | 0.82 | MMP1 (0.64) | MMP13MMP1MMP9ADAM17MMP2 | |
| SCHEMBL7297023 | 0.81 | ALDH1A1 (0.47) | ALDH1A1GAASMN1; SMN2LMNAMAPK1 | |
| SCHEMBL7307938 | 0.80 | MMP13 (0.70) | MMP13MMP1MMP9ADAM17MMP2 | |
| SCHEMBL7309131 | 0.79 | MMP1 (0.39) | MMP13MMP1MMP9ADAM17MMP2 | |
| SCHEMBL6998853 | 0.75 | MMP1 (0.56) | MMP13MMP1MMP9ADAM17ALDH1A1 | |
| SCHEMBL7001941 | 0.75 | MMP1 (0.56) | MMP13MMP1MMP9ADAM17ALDH1A1 | |
| SCHEMBL7302297 | 0.75 | MEN1 (0.44) | MMP13ADAM17ALDH1A1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |