Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 15/20 | 0.56 |
| ▸ | MMP1 | P03956 | 14/20 | 0.56 |
| ▸ | MMP9 | P14780 | 10/20 | 0.56 |
| ▸ | ADAM17 | P78536 | 8/20 | 0.56 |
| ▸ | MMP3 | P08254 | 5/20 | 0.47 |
| ▸ | MMP8 | P22894 | 5/20 | 0.47 |
| ▸ | MMP14 | P50281 | 5/20 | 0.47 |
| ▸ | MMP2 | P08253 | 5/20 | 0.47 |
| ▸ | MMP7 | P09237 | 3/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | MMP10 | P09238 | 1/20 | 0.47 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7304591 | 0.86 | MMP1 (0.64) | MMP13MMP1MMP9ADAM17MMP3 | |
| SCHEMBL7309706 | 0.84 | MMP13 (0.57) | MMP13MMP1MMP9ADAM17MMP3 | |
| SCHEMBL7304852 | 0.82 | MMP13 (0.45) | MMP13MMP1MMP9ADAM17MMP3 | |
| SCHEMBL7309299 | 0.80 | MMP1 (0.46) | MMP13MMP1MMP9ADAM17MMP3 | |
| SCHEMBL6998853 | 0.79 | MMP1 (0.56) | MMP13MMP1MMP9ADAM17MMP3 | |
| SCHEMBL7001941 | 0.79 | MMP1 (0.56) | MMP13MMP1MMP9ADAM17MMP3 | |
| SCHEMBL7310372 | 0.78 | MMP13 (0.76) | MMP13MMP1MMP9ADAM17MMP3 | |
| SCHEMBL3948394 | 0.78 | ADAM17 (0.67) | MMP13MMP1MMP9ADAM17MMP14 | |
| SCHEMBL7509852 | 0.76 | MMP13 (0.64) | MMP13MMP1MMP9ADAM17MMP3 | |
| SCHEMBL7309131 | 0.76 | MMP1 (0.39) | MMP13MMP1MMP9ADAM17MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |