Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 12/20 | 0.57 |
| ▸ | MMP9 | P14780 | 11/20 | 0.57 |
| ▸ | MMP1 | P03956 | 11/20 | 0.57 |
| ▸ | ADAM17 | P78536 | 7/20 | 0.57 |
| ▸ | MMP3 | P08254 | 5/20 | 0.46 |
| ▸ | MMP14 | P50281 | 4/20 | 0.46 |
| ▸ | MMP2 | P08253 | 4/20 | 0.46 |
| ▸ | MMP7 | P09237 | 3/20 | 0.46 |
| ▸ | MMP8 | P22894 | 3/20 | 0.46 |
| ▸ | MMP10 | P09238 | 2/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.42 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7304852 | 0.89 | MMP13 (0.45) | MMP13MMP9MMP1ADAM17MMP3 | |
| SCHEMBL7309299 | 0.84 | MMP1 (0.46) | MMP13MMP9MMP1ADAM17MMP3 | |
| SCHEMBL7304591 | 0.84 | MMP1 (0.64) | MMP13MMP9MMP1ADAM17MMP3 | |
| SCHEMBL7310855 | 0.84 | MMP13 (0.56) | MMP13MMP9MMP1ADAM17MMP3 | |
| SCHEMBL7309131 | 0.80 | MMP1 (0.39) | MMP13MMP9MMP1ADAM17MMP3 | |
| SCHEMBL7301851 | 0.79 | MMP13 (0.73) | MMP13MMP9MMP1ADAM17MMP3 | |
| SCHEMBL7297023 | 0.79 | ALDH1A1 (0.47) | SMN1; SMN2LMNAALDH1A1GAA | |
| SCHEMBL6998853 | 0.77 | MMP1 (0.56) | MMP13MMP9MMP1ADAM17MMP3 | |
| SCHEMBL7001941 | 0.77 | MMP1 (0.56) | MMP13MMP9MMP1ADAM17MMP3 | |
| SCHEMBL13898934 | 0.74 | MMP13 (0.48) | MMP13MMP9MMP1ADAM17MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |