Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.69 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.59 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.58 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | THPO | P40225 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28308377 | 0.98 | NR4A2 (0.67) | NR4A2CREBBPKDM4ELMNAPKM | |
| Hydrochloric Acid SCHEMBL30718988 | 0.98 | NR4A2 (0.67) | NR4A2CREBBPKDM4ELMNAPKM | |
| SCHEMBL376662 | 0.89 | GABRA1 (0.69) | KDM4EPKMMEN1KMT2AGABRA1 | |
| SCHEMBL29475801 | 0.89 | GABRA1 (0.69) | KDM4EPKMMEN1KMT2AGABRA1 | |
| Hydrochloric Acid SCHEMBL29008098 | 0.88 | GABRA1 (0.67) | KDM4EPKMMEN1KMT2AGABRA1 | |
| Hydrochloric Acid SCHEMBL30417898 | 0.88 | GABRA1 (0.67) | KDM4EPKMMEN1KMT2AGABRA1 | |
| SCHEMBL5805847 | 0.88 | NR4A2 (0.65) | NR4A2CREBBPKDM4ELMNAPBRM1 | |
| SCHEMBL27961666 | 0.85 | TSHR (0.66) | NR4A2CREBBPKDM4ELMNAGABRA1 | |
| SCHEMBL7170554 | 0.85 | NR4A2 (0.57) | NR4A2CREBBPLMNAPKMPBRM1 | |
| SCHEMBL368012 | 0.84 | GABRA1 (0.58) | NR4A2CREBBPLMNAPKMPBRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 172 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117362291-A | Tetrahydro-beta-carboline phenol derivative, preparation method and application thereof, and whitening cream | 广州番禺职业技术学院 | 2024-01-09 | — | — | CN | claimed |
| WO-2023078369-A1 | BICYCLIC COMPOUND AND APPLICATION THEREOF | 贝达药业股份有限公司 | 2023-05-11 | — | — | WO | claimed |
| CN-110003187-B | Polyfluoroalkyl substituted benzofuran compound and preparation method thereof | 南京工业大学 | 2021-11-05 | — | — | CN | claimed |
| CN-111635352-B | Indole alkaloid in traditional Chinese medicine herba Rubi Corchorifolii, and extraction and purification method and application thereof | 贵州中医药大学 | 2021-09-07 | — | — | CN | claimed |
| CN-111635352-A | Indole alkaloid in traditional Chinese medicine herba Rubi Corchorifolii, and extraction and purification method and application thereof | 贵州中医药大学 | 2020-09-08 | — | — | CN | claimed |
| CN-108840868-B | The preparation method and application of trypoline ketone compounds with anti-tumor activity | 上海山的实业有限公司 | 2019-10-18 | — | — | CN | claimed |
| CN-106083691-B | A kind of preparation method of arbidol HCl monohydrate | 山东罗欣药业集团恒欣药业有限公司 | 2018-11-27 | — | — | CN | claimed |
| CN-108864089-A | A kind of new indole and pyridone drug molecule and its preparation method and application | 河南湾流生物科技有限公司 | 2018-11-23 | — | — | CN | claimed |
| CN-108840868-A | The preparation method and application of trypoline ketone compounds with anti-tumor activity | 河南湾流生物科技有限公司 | 2018-11-20 | — | — | CN | claimed |
| CN-105968095-B | Indoles virtue sulfone derivatives and the preparation method and application thereof | 山东大学 | 2018-10-30 | — | — | CN | claimed |
| CN-108546245-A | A kind of preparation method of antiproliferative activity intermediate ML-098 | 绍兴文理学院 | 2018-09-18 | — | — | CN | claimed |
| CN-104744460-B | β carbolines, dihydro β carbolines and tetrahydro-beta-carboline alcaloid-derivatives and preparation method thereof and the application in terms of preventing and treating plant virus, sterilization, desinsection | 南开大学 | 2017-06-16 | — | — | CN | claimed |
| CN-105968095-A | Indolylaryl-sulfone derivative, as well as preparation method and application thereof | 山东大学 | 2016-09-28 | — | — | CN | claimed |
| CN-105601555-A | Method for preparing nitroindole derivatives | UNIV SOOCHOW | 2016-05-25 | — | — | CN | claimed |
| CN-104754941-A | Proneurogenic compounds | UNIV TEXAS | 2015-07-01 | — | — | CN | claimed |
| US-20150164860-A1 | ANTICANCER TREATMENT METHODS INVOLVING ANALOGS AND DERIVATIVES OF 3-(2-SUBSTITUTED-ETHYL) INDOLE COMPOUNDS | TUSKEGEE UNIVERSITY (US) | 2015-06-18 | — | — | US | claimed |
| CN-102786463-B | Method for preparing 5-acetoxyl-3-indole carboxylic acid ethyl ester | ZHEJIANG GENEBEST PHARMACEUTICAL CO LTD | 2013-12-18 | — | — | CN | claimed |
| CN-102786463-A | Method for preparing 5-acetoxyl-3-indole carboxylic acid ethyl ester | ZHEJIANG GENEBEST PHARMACEUTICAL CO LTD | 2012-11-21 | — | — | CN | claimed |
| CN-101597254-B | Method for preparing trandolapril intermediate | Shanghai jinshan pharmaceutical co ltd | 2012-11-14 | — | — | CN | claimed |
| CN-112239468-B | Metal-free solvent-free synthesis of fused pyridine heterocycles and biomedical applications thereof | 印多尔印度理工学院 | 2025-05-27 | — | — | CN | disclosed |
| CN-114555585-B | HPK1 inhibitors and uses thereof | 锐格药业公司 | 2025-02-11 | — | — | CN | disclosed |
| US-20240175141-A1 | BIOBASED AND BIODEGRADABLE CORROSION INHIBITION COMPOSITION | ZestBio, Inc. | 2024-05-30 | — | — | US | disclosed |
| CN-115572269-B | N-trifluoro isopropyl azole and indole compound and preparation method thereof | 广州大学 | 2024-05-17 | — | — | CN | disclosed |
| WO-2024081967-A2 | BIOBASED AND BIODEGRADABLE CORROSION INHIBITION COMPOSITION | ZestBio, Inc. (US) | 2024-04-18 | — | — | WO | disclosed |
| CN-117362291-A | Tetrahydro-beta-carboline phenol derivative, preparation method and application thereof, and whitening cream | 广州番禺职业技术学院 | 2024-01-09 | — | — | CN | disclosed |
| CN-115304597-B | Beta-carboline compounds and application thereof in preparation of medicines for treating or preventing tumor diseases | 中国科学院深圳先进技术研究院 | 2023-10-20 | — | — | CN | disclosed |
| US-20230142119-A1 | TETRACYCLIC COMPOUND | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2023-05-11 | — | — | US | disclosed |
| WO-2023078369-A1 | BICYCLIC COMPOUND AND APPLICATION THEREOF | 贝达药业股份有限公司 | 2023-05-11 | — | — | WO | disclosed |
| CN-115916749-A | Substituted 5-hydroxyindole compounds as alpha-1 antitrypsin modulators | 弗特克斯药品有限公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-107709290-B | Selective Androgen Receptor Degrader (SARD) ligands and methods of use thereof | GTX公司 | 2023-02-28 | — | — | CN | disclosed |
| CN-115572269-A | N-trifluoro isopropyl azole and indole compound and preparation method thereof | 广州大学 | 2023-01-06 | — | — | CN | disclosed |
| CN-115335380-A | Tricyclic heteroaryl compounds useful as IRAK4 inhibitors | 百时美施贵宝公司 | 2022-11-11 | — | — | CN | disclosed |
| CN-115304597-A | Beta-carboline compounds and application thereof in preparing medicines for treating or preventing tumor diseases | 中国科学院深圳先进技术研究院 | 2022-11-08 | — | — | CN | disclosed |
| US-20220306578-A1 | TETRACYCLIC COMPOUND | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2022-09-29 | — | — | US | disclosed |
| CN-114031541-B | Preparation method of 2-substituted 3-methylindole derivative | 太原理工大学 | 2022-08-19 | — | — | CN | disclosed |
| CN-114555585-A | HPK1 inhibitors and uses thereof | 上海齐鲁锐格医药研发有限公司 | 2022-05-27 | — | — | CN | disclosed |
| EP-3459950-B1 | TETRAHYDRO-BETA-CARBOLINE ALKALOID DERIVATIVES, METHOD FOR PREPARING THE SAME AND USE IN ASPECTS OF PREVENTING AND TREATING PLANT VIRUSES, AS FUNGICIDES AND INSECTICIDES | JINGBO AGROCHEMICALS TECH CO LTD (CN) | 2022-05-18 | — | — | EP | disclosed |
| EP-3459951-B1 | TETRAHYDRO-BETA-CARBOLINE ALKALOID DERIVATIVES, METHOD FOR PREPARING THE SAME AND USE IN ASPECTS OF PREVENTING AND TREATING PLANT VIRUSES, AS FUNGICIDES AND INSECTICIDES | JINGBO AGROCHEMICALS TECH CO LTD (CN) | 2022-05-11 | — | — | EP | disclosed |
| CN-114031541-A | Preparation method of 2-substituted 3-methylindole derivative | 太原理工大学 | 2022-02-11 | — | — | CN | disclosed |
| CN-110003187-B | Polyfluoroalkyl substituted benzofuran compound and preparation method thereof | 南京工业大学 | 2021-11-05 | — | — | CN | disclosed |
| CN-111635352-B | Indole alkaloid in traditional Chinese medicine herba Rubi Corchorifolii, and extraction and purification method and application thereof | 贵州中医药大学 | 2021-09-07 | — | — | CN | disclosed |
| CN-109328059-B | Selective inhibitors of clinically important mutants of EGFR tyrosine kinase | CS制药技术有限公司 | 2021-08-17 | — | — | CN | disclosed |
| CN-112135613-A | Kinase inhibitor compounds and compositions and methods of use | 西奈山伊坎医学院 | 2020-12-25 | — | — | CN | disclosed |
| CN-111635352-A | Indole alkaloid in traditional Chinese medicine herba Rubi Corchorifolii, and extraction and purification method and application thereof | 贵州中医药大学 | 2020-09-08 | — | — | CN | disclosed |
| CN-104311472-B9 | Substituted 1,2,3, 4-tetrahydrocyclopenta [ b ] indol-3-yl acetic acid derivatives | 艾尼纳制药公司 | 2020-03-17 | — | — | CN | disclosed |
| CN-104311472-B | Substituted 1,2,3, 4-tetrahydrocyclopenta [ b ] indol-3-yl acetic acid derivatives | 艾尼纳制药公司 | 2019-12-31 | — | — | CN | disclosed |
| CN-110483366-A | Benzazole compounds and preparation method thereof, pharmaceutical composition and purposes | INST MATERIA MEDICA CAMS | 2019-11-22 | — | — | CN | disclosed |
| CN-108840868-B | The preparation method and application of trypoline ketone compounds with anti-tumor activity | 上海山的实业有限公司 | 2019-10-18 | — | — | CN | disclosed |
| EP-3459951-A1 | BETA-CARBOLINE, DIHYDRO-BETA-CARBOLINE AND TETRAHYDRO-BETA-CARBOLINE ALKALOID DERIVATIVES, METHOD FOR PREPARING THE SAME AND USE IN ASPECTS OF PREVENTING AND TREATING PLANT VIRUSES, AS FUNGICIDES AND INSECTICIDES | Nankai University (CN) | 2019-03-27 | — | — | EP | disclosed |
| EP-3459950-A1 | BETA-CARBOLINE, DIHYDRO-BETA-CARBOLINE AND TETRAHYDRO-BETA-CARBOLINE ALKALOID DERIVATIVES, METHOD FOR PREPARING THE SAME AND USE IN ASPECTS OF PREVENTING AND TREATING PLANT VIRUSES, AS FUNGICIDES AND INSECTICIDES | Nankai University (CN) | 2019-03-27 | — | — | EP | disclosed |
| US-10208033-B2 | β-carboline, dihydro-β-carboline and tetrahydro-β-carboline alkaloid derivatives and preparation methods same and use in aspects of preventing and treating plant viruses, fungicides and insecticides | NANKAI UNIVERSITY (CN) | 2019-02-19 | — | — | US | disclosed |
| CN-109328059-A | Selective inhibitors of clinically important mutants of EGFR tyrosine kinase | CS制药技术有限公司 | 2019-02-12 | — | — | CN | disclosed |
| CN-109311890-A | BET protein degradation agent | 密执安大学评议会 | 2019-02-05 | — | — | CN | disclosed |
| CN-106083691-B | A kind of preparation method of arbidol HCl monohydrate | 山东罗欣药业集团恒欣药业有限公司 | 2018-11-27 | — | — | CN | disclosed |
| CN-108864089-A | A kind of new indole and pyridone drug molecule and its preparation method and application | 河南湾流生物科技有限公司 | 2018-11-23 | — | — | CN | disclosed |
| CN-108840868-A | The preparation method and application of trypoline ketone compounds with anti-tumor activity | 河南湾流生物科技有限公司 | 2018-11-20 | — | — | CN | disclosed |
| CN-108770356-A | The tricyclic compounds and its preparation of bromodomain protein inhibitor, pharmaceutical composition and purposes | 正大天晴药业集团股份有限公司 | 2018-11-06 | — | — | CN | disclosed |
| CN-105968095-B | Indoles virtue sulfone derivatives and the preparation method and application thereof | 山东大学 | 2018-10-30 | — | — | CN | disclosed |
| CN-108546245-A | A kind of preparation method of antiproliferative activity intermediate ML-098 | 绍兴文理学院 | 2018-09-18 | — | — | CN | disclosed |
| CN-105601555-B | A method of preparing nitroindole derivative | 苏州大学 | 2018-07-31 | — | — | CN | disclosed |
| US-9926282-B2 | Phthalazinones and isoquinolinones as rock inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-03-27 | — | — | US | disclosed |
| US-9877949-B2 | Anticancer treatment methods involving analogs and derivatives of 3-(2-substituted-ethyl) indole compounds | TUSKEGEE UNIVERSITY (US) | 2018-01-30 | — | — | US | disclosed |
| EP-2661433-B1 | INDOLE COMPOUNDS OR ANALOGUES THEREOF USEFUL FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION (AMD) | NOVARTIS AG (CH) | 2017-08-16 | — | — | EP | disclosed |
| CN-104744460-B | β carbolines, dihydro β carbolines and tetrahydro-beta-carboline alcaloid-derivatives and preparation method thereof and the application in terms of preventing and treating plant virus, sterilization, desinsection | 南开大学 | 2017-06-16 | — | — | CN | disclosed |
| CN-104030971-B | A kind of method synthesizing carbazole alkaloid karapinchamine A | 浙江大学 | 2016-12-07 | — | — | CN | disclosed |
| EP-3091015-A1 | BETA-CARBOLINE, DIHYDRO-BETA-CARBOLINE AND TETRAHYDRO-BETA-CARBOLINE ALKALOID DERIVATIVES AND METHOD FOR PREPARING SAME AND USE IN ASPECTS OF PREVENTING AND TREATING PLANT VIRUSES, FUNGICIDES AND INSECTICIDES | Nankai University (CN) | 2016-11-09 | — | — | EP | disclosed |
| CN-105968095-A | Indolylaryl-sulfone derivative, as well as preparation method and application thereof | 山东大学 | 2016-09-28 | — | — | CN | disclosed |
| CN-105622486-A | Diindolylmethane compound as well as synthesis method and application thereof | NANJING POLYTECHNIC INST | 2016-06-01 | — | — | CN | disclosed |
| CN-105601555-A | Method for preparing nitroindole derivatives | UNIV SOOCHOW | 2016-05-25 | — | — | CN | disclosed |
| CN-103626793-B | There is SPIROBODIPYs compounds, the preparation method and its usage of spiro-pyrans structure | EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2016-02-10 | — | — | CN | disclosed |
| US-20150353505-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2015-12-10 | — | — | US | disclosed |
| US-20150353505-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2015-12-10 | — | — | US | disclosed |
| US-9085555-B2 | Complement pathway modulators and uses thereof | NOVARTIS AG (CH) | 2015-07-21 | — | — | US | disclosed |
| CN-104754941-A | Proneurogenic compounds | UNIV TEXAS | 2015-07-01 | — | — | CN | disclosed |
| US-20150164860-A1 | ANTICANCER TREATMENT METHODS INVOLVING ANALOGS AND DERIVATIVES OF 3-(2-SUBSTITUTED-ETHYL) INDOLE COMPOUNDS | TUSKEGEE UNIVERSITY (US) | 2015-06-18 | — | — | US | disclosed |
| CN-103130802-B | Tetrahydro-gamma-carboline derivative synthesis method | UNIV TIANJIN | 2015-05-13 | — | — | CN | disclosed |
| US-8993523-B2 | Dimeric IAP inhibitors | NOVARTIS AG (CH) | 2015-03-31 | — | — | US | disclosed |
| CN-103402996-B | Indole compounds or analogues thereof useful for the treatment of age-related macular degeneration (AMD) | NOVARTIS AG | 2015-02-11 | — | — | CN | disclosed |
| CN-104311472-A | Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives | ARENA PHARM INC | 2015-01-28 | — | — | CN | disclosed |
| US-20140349989-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | ALZHEIMER'S INSTITUTE OF AMERICA (US) | 2014-11-27 | — | — | US | disclosed |
| US-20140349989-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | ALZHEIMER'S INSTITUTE OF AMERICA (US) | 2014-11-27 | — | — | US | disclosed |
| CN-103347874-B | dimeric IAP inhibitors | NOVARTIS AG (CH) | 2014-10-29 | — | — | CN | disclosed |
| CN-102164891-B | Substituted 1,2,3, 4-tetrahydrocyclopenta [ b ] indol-3-yl acetic acid derivatives useful for the treatment of autoimmune and inflammatory diseases | ARENA PHARM INC | 2014-09-03 | — | — | CN | disclosed |
| CN-103929961-A | Compounds and therapeutic uses thereof | MYREXIS INC | 2014-07-16 | — | — | CN | disclosed |
| CN-102209711-B | Compounds for the treatment of hepatitis C | BRISTOL MYERS SQUIBB CO | 2014-06-18 | — | — | CN | disclosed |
| CN-103864783-A | Compounds for the Treatment of Hepatitis C | BRISTOL MYERS SQUIBB CO | 2014-06-18 | — | — | CN | disclosed |
| EP-2739144-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | Alzheimer's Institute of America, Inc. (US) | 2014-06-11 | — | — | EP | disclosed |
| CN-103626793-A | SPIROBODIPYs compound with spiropyrane structure as well as preparation method and application of compound | UNIV EAST CHINA SCIENCE & TECH | 2014-03-12 | — | — | CN | disclosed |
| CN-103497184-A | Pyrrolo-and thiazolo-pyridine compounds as HIF modulators | FIBROGEN INC | 2014-01-08 | — | — | CN | disclosed |
| US-20130309247-A1 | DIMERIC IAP INHIBITORS | NOVARTIS AG (CH) | 2013-11-21 | — | — | US | disclosed |
| CN-103402996-A | Indole compounds or analogues thereof useful for the treatment of age-related macular degeneration (AMD) | NOVARTIS AG | 2013-11-20 | — | — | CN | disclosed |
| EP-2661433-A1 | INDOLE COMPOUNDS OR ANALOGUES THEREOF USEFUL FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION (AMD) | Novartis AG (CH) | 2013-11-13 | — | — | EP | disclosed |
| CN-103380191-A | Compounds for electronic devices | MERCK PATENT GMBH | 2013-10-30 | — | — | CN | disclosed |
| EP-2651919-A1 | DIMERIC IAP INHIBITORS | Novartis AG (CH) | 2013-10-23 | — | — | EP | disclosed |
| CN-103347874-A | Dimeric iap inhibitors | NOVARTIS AG | 2013-10-09 | — | — | CN | disclosed |
| CN-103339134-A | Tricyclic pyrrolo derivatives, process for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL | 2013-10-02 | — | — | CN | disclosed |
| CN-103130802-A | Tetrahydro-gamma-carboline derivative synthesis method | UNIV TIANJIN | 2013-06-05 | — | — | CN | disclosed |
| CN-102906089-A | Compounds for the treatment of hepatitis C | BRISTOL MYERS SQUIBB CO | 2013-01-30 | — | — | CN | disclosed |
| WO-2012177782-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYREXIS, INC. (US) | 2012-12-27 | — | — | WO | disclosed |
| WO-2012177782-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYREXIS, INC. (US) | 2012-12-27 | — | — | WO | disclosed |
| US-20120295884-A1 | Complement pathway modulators and uses thereof | NOVARTIS AG (CH) | 2012-11-22 | — | — | US | disclosed |
| CN-101597254-B | Method for preparing trandolapril intermediate | Shanghai jinshan pharmaceutical co ltd | 2012-11-14 | — | — | CN | disclosed |
| WO-2012114252-A1 | NOVEL INDOLE AND PYRROLOPYRIDINE AMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-08-30 | — | — | WO | disclosed |
| WO-2012093101-A1 | INDOLE COMPOUNDS OR ANALOGUES THEREOF USEFUL FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION (AMD) | NOVARTIS AG (CH) | 2012-07-12 | — | — | WO | disclosed |
| WO-2012080271-A1 | DIMERIC IAP INHIBITORS | NOVARTIS AG (CH) | 2012-06-21 | — | — | WO | disclosed |
| US-8148413-B2 | N-heteroaryl indole carboxamides and analogues thereof, for use as glucokinase activators in the treatment of diabetes | TRANSTECH PHARMA, INC. (US) | 2012-04-03 | — | — | US | disclosed |
| US-8138173-B2 | Pyrazolo[3,4-C]quinolines, pyrazolo[3,4-C]naphthyridines, analogs thereof, and methods | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2012-03-20 | — | — | US | disclosed |
| US-8013153-B2 | Substituted pyrimidine kinase inhibitors | JANSSEN PHARMACEUTICA, N.V. (BE) | 2011-09-06 | — | — | US | disclosed |
| CN-102164891-A | Substituted 1,2,3, 4-tetrahydrocyclopenta [ b ] indol-3-yl acetic acid derivatives useful for the treatment of autoimmune and inflammatory diseases | ARENA PHARM INC | 2011-08-24 | — | — | CN | disclosed |
| CN-101575331-B | Preparation method of 5'-((5-MethoxyMethoxy-2- phenylindole-1-yl)methylene)-2'-oxo-3'- methylenetetrahydrofuran | SHANGHAI INST MATERIA MEDICA | 2011-07-20 | — | — | CN | disclosed |
| US-20110082144-A1 | N-HETEROARYL INDOLE CARBOXAMIDES AND ANALOGUES THEREOF, FOR USE AS GLUCOKINASE ACTIVATORS IN THE TREATMENT OF DIABETES | TRANSTECH PHARMA, INC. (US) | 2011-04-07 | — | — | US | disclosed |
| CN-101945862-A | Tetrahydrocyclopenta [ b ] indol-3-yl carboxylic acid derivatives for the treatment of autoimmune and inflammatory disorders | ARENA PHARM INC | 2011-01-12 | — | — | CN | disclosed |
| US-7812043-B2 | N-heteroaryl indole carboxamides and analogues thereof, for use as glucokinase activators in the treatment of diabetes | TRANSTECH PHARMA, INC. (US) | 2010-10-12 | — | — | US | disclosed |
| EP-1836163-B1 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | NOVARTIS AG (CH) | 2010-09-22 | — | — | EP | disclosed |
| CN-101842353-A | 2, 3-substituted indole derivatives for treating viral infections | SCHERING CORP | 2010-09-22 | — | — | CN | disclosed |
| US-20100087427-A1 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | BREITENSTEIN WERNER | 2010-04-08 | — | — | US | disclosed |
| CN-101687789-A | Novel inhibitors hepatitis c virus replication | INTERMUNE INC | 2010-03-31 | — | — | CN | disclosed |
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| US-20090047246-A1 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2009-02-19 | — | — | US | disclosed |
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| WO-2008100867-A2 | NOVEL INHIBITORS HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2008-08-21 | — | — | WO | disclosed |
| WO-2008100867-A2 | NOVEL INHIBITORS HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2008-08-21 | — | — | WO | disclosed |
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| WO-2007115315-A2 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN, INC. (US) | 2007-10-11 | — | — | WO | disclosed |
| EP-1838669-A1 | INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION | Biolipox AB (SE) | 2007-10-03 | — | — | EP | disclosed |
| EP-1836163-A2 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | Novartis AG (CH) | 2007-09-26 | — | — | EP | disclosed |
| CN-101035528-A | Carbazole and cyclopentaindole derivatives to treat infection with hepatitis C virus | WYETH CORP (US) | 2007-09-12 | — | — | CN | disclosed |
| US-20070027140-A1 | N-heteroaryl indole carboxamides and analogues thereof, for use as glcokinase activators in the treatment of diabetes | NOVO NORDISK A/S (DK) | 2007-02-01 | — | — | US | disclosed |
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| WO-2006077365-A1 | INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION | BIOLIPOX AB (SE) | 2006-07-27 | — | — | WO | disclosed |
| US-7081472-B2 | Substituted bis-indole derivatives useful as contrast agents, pharmaceutical compositions containing them and intermediates for producing them | K. U. LEUVEN RESEARCH & DEVELOPMENT (BE) | 2006-07-25 | — | — | US | disclosed |
| WO-2006066896-A2 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | NOVARTIS AG (CH) | 2006-06-29 | — | — | WO | disclosed |
| EP-1670758-A1 | SUBSTITUTED INDOLE ACID DERIVATIVES AND THEIR USE AS PAI-1 INHIBITORS | Wyeth (US) | 2006-06-21 | — | — | EP | disclosed |
| US-20060089355-A1 | Methods of treating alzheimer's disease using aromatically substituted w-amino-alkanoic acid amides and alkanoic acid diamides | ELAN PHARMACEUTICALS, INC. | 2006-04-27 | — | — | US | disclosed |
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| WO-2005030717-A1 | SUBSTITUTED INDOLE ACID DERIVATIVES AND THEIR USE AS PAI-1 INHIBITORS | WYETH (US) | 2005-04-07 | — | — | WO | disclosed |
| CN-1486299-A | Substituted bis-indole derivatives useful as contrast agents, pharmaceutical compositions containing them and intermediates for producing them | ³�������̴�ѧ�о������� | 2004-03-31 | — | — | CN | disclosed |
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Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (16 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230142119-A1 | TETRACYCLIC COMPOUND | ALK, TTR, ACVR1 | NR4A2 1417/4885CREBBP 565/4885KDM4E 903/4885 |
| US-20130309247-A1 | DIMERIC IAP INHIBITORS | XIAP, BIRC5, BIRC2 | NR4A2 3995/4885CREBBP 3960/4885KDM4E 3847/4885 |
| US-20100087427-A1 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | REN, ACE, PEPD | NR4A2 2768/4885CREBBP 3433/4885KDM4E 1562/4885 |
| US-20090069299-A1 | Pyrazolo[3,4-c]Quinolines, Pyrazolo[3,4-c]Naphthyridines, Analogs Thereof, and Methods | IL4, IL2, IL5 | NR4A2 524/4885CREBBP 2322/4885KDM4E 3301/4885 |
| US-20140349989-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | NFATC1, CD4, CD47 | NR4A2 1440/4885CREBBP 1002/4885KDM4E 2413/4885 |
| US-20090028796-A1 | PESTICIDAL COMPOSITION COMPRISING INDOLE DERIVATES | IDO1, IDO2, INMT | NR4A2 4675/4885CREBBP 3434/4885KDM4E 2045/4885 |
| US-20060089355-A1 | Methods of treating alzheimer's disease using aromatically substituted w-amino-alkanoic acid amides and alkanoic acid diamides | APP, BACE1, BACE2 | NR4A2 1646/4885CREBBP 3475/4885KDM4E 1951/4885 |
| US-20070027140-A1 | N-heteroaryl indole carboxamides and analogues thereof, for use as glcokinase activators in the treatment of diabetes | GALK1, GCKR, GCK | NR4A2 3136/4885CREBBP 692/4885KDM4E 3576/4885 |
| US-20220306578-A1 | TETRACYCLIC COMPOUND | ALK, TTR, ACVR1 | NR4A2 1417/4885CREBBP 565/4885KDM4E 903/4885 |
| US-20040053911-A1 | Substituted bis-indole derivatives useful as contrast agents, pharmaceutical compositions containing them and intermediates for producing them | IDO1, IDO2, CNR1 | NR4A2 3813/4885CREBBP 2278/4885KDM4E 3436/4885 |
| US-20150353505-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | MYLK, MYLK2, ROCK1 | NR4A2 3147/4885CREBBP 2094/4885KDM4E 1029/4885 |
| US-20120295884-A1 | Complement pathway modulators and uses thereof | C5, C3AR1, C9 | NR4A2 3611/4885CREBBP 3979/4885KDM4E 4092/4885 |
| US-20150164860-A1 | ANTICANCER TREATMENT METHODS INVOLVING ANALOGS AND DERIVATIVES OF 3-(2-SUBSTITUTED-ETHYL) INDOLE COMPOUNDS | MCL1, BAD, API5 | NR4A2 2986/4885CREBBP 1458/4885KDM4E 836/4885 |
| US-20090047246-A1 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION | EIF2AK2, HAVCR2, HCCS | NR4A2 2355/4885CREBBP 431/4885KDM4E 1400/4885 |
| US-20110082144-A1 | N-HETEROARYL INDOLE CARBOXAMIDES AND ANALOGUES THEREOF, FOR USE AS GLUCOKINASE ACTIVATORS IN THE TREATMENT OF DIABETES | GCKR, GCK, GALK1 | NR4A2 1634/4885CREBBP 780/4885KDM4E 2135/4885 |
| US-10208033-B2 | β-carboline, dihydro-β-carboline and tetrahydro-β-carboline alkaloid derivatives and preparation methods same and use in aspects of preventing and treating plant viruses, fungicides and insecticides | DDT, ZC3HAV1, NOTUM | NR4A2 2815/4885CREBBP 4765/4885KDM4E 1731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.