Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7306214 | 0.92 | SIGMAR1 (0.46) | KDM4ELMNASIGMAR1HTR1ADRD4 | |
| SCHEMBL7303442 | 0.91 | HTR7 (0.47) | KDM4ELMNASIGMAR1HTR1ADRD4 | |
| SCHEMBL7359856 | 0.88 | KDM4E (0.44) | KDM4ELMNASIGMAR1HTR1ADRD4 | |
| SCHEMBL7310638 | 0.83 | KDM4E (0.43) | KDM4ELMNASIGMAR1HTR1ADRD4 | |
| SCHEMBL7360979 | 0.83 | DRD3 (0.44) | KDM4ESIGMAR1HTR1ADRD3HTR7 | |
| SCHEMBL7297468 | 0.82 | DRD3 (0.41) | KDM4ESIGMAR1HTR1ADRD4DRD3 | |
| SCHEMBL7307166 | 0.82 | KDM4E (0.43) | KDM4ELMNASIGMAR1HTR1ADRD4 | |
| SCHEMBL7300303 | 0.82 | HTR1A (0.46) | KDM4ESIGMAR1HTR1ADRD3ALDH1A1 | |
| SCHEMBL7306783 | 0.82 | HTR1A (0.46) | KDM4ESIGMAR1HTR1ADRD3ALDH1A1 | |
| SCHEMBL7302447 | 0.81 | PARP1 (0.42) | KDM4ESIGMAR1HTR1ADRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5304560-A | Treating CNS disorders; dopamine receptor antagonist | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-19 | — | — | US | disclosed |
| EP-0481342-A1 | Quinazoline derivatives and their preparation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-22 | — | — | EP | disclosed |