Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | SLC6A9 | P48067 | 15/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7996500 | 0.84 | SLC6A4 (0.72) | SLC6A4HRH3SLC6A9 | |
| SCHEMBL1171368 | 0.76 | SLC6A9 (0.68) | SLC6A9 | |
| SCHEMBL8971145 | 0.76 | SLC6A4 (0.51) | SLC6A4HRH3SLC6A9 | |
| Oxalic Acid SCHEMBL7306543 | 0.74 | KDM4E (0.61) | SLC6A4HRH3SLC6A9 | |
| SCHEMBL8971666 | 0.74 | SLC6A4 (0.49) | SLC6A4HRH3SLC6A9 | |
| Fumaric Acid SCHEMBL9445703 | 0.73 | SLC6A9 (0.47) | SLC6A4HRH3SLC6A9 | |
| SCHEMBL8971243 | 0.73 | SLC6A9 (0.44) | SLC6A4HRH3SLC6A9 | |
| SCHEMBL3894545 | 0.70 | CYP2D6 (0.64) | SLC6A4HRH3SLC6A9 | |
| SCHEMBL685134 | 0.70 | SLC6A4 (0.70) | SLC6A4HRH3SLC6A9 | |
| SCHEMBL8197707 | 0.70 | CYP2D6 (0.64) | SLC6A4HRH3SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4626549-A | Treatment of obesity with aryloxyphenylpropylamines | ELI LILLY AND COMPANY (US) | 1986-12-02 | — | — | US | disclosed |
| US-4314081-A | ANTIDEPRESSANTS | ELI LILLY AND COMPANY (US) | 1982-02-02 | — | — | US | disclosed |
| US-4194009-A | ANTIDEPRESSANT | ELI LILLY AND COMPANY (US) | 1980-03-18 | — | — | US | disclosed |
| US-4018895-A | Aryloxyphenylpropylamines in treating depression | ELI LILLY AND COMPANY (US) | 1977-04-19 | — | — | US | disclosed |