SCHEMBL7996500

SCHEMBL7996500

CN(C)CCC(Oc1ccc(C(F)(F)F)cc1)c1ccccc1.Cc1ccc(S(=O)(=O)O)cc1

nearest known ligand 0.72

Known targets — ChEMBL curated mechanism

ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
OPRM1 known ✓ P35372 1/20 0.51
SLC6A4 P31645 5/20 0.72
HRH3 Q9Y5N1 3/20 0.72
SLC6A9 P48067 11/20 0.61
SLC6A2 P23975 3/20 0.51
SLC6A3 Q01959 3/20 0.51
KCNK2 O95069 2/20 0.51
KCNH2 Q12809 2/20 0.51
CACNA1C Q13936 2/20 0.51
NPC1 O15118 2/20 0.51
CYP2D6 P10635 2/20 0.51
CYP2C19 P33261 2/20 0.51
MTOR P42345 2/20 0.51
RAB9A P51151 2/20 0.51
MEN1 O00255 2/20 0.51
KMT2A Q03164 2/20 0.51
LMNA P02545 2/20 0.51
KDM4E B2RXH2 1/20 0.51
TP53 P04637 1/20 0.51
CYP1A2 P05177 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL679320 0.85 SLC6A4 (1.00) SLC6A4HRH3SLC6A9SLC6A2SLC6A3
SCHEMBL29700710 0.85 SLC6A4 (1.00) SLC6A4HRH3SLC6A9SLC6A2SLC6A3
SCHEMBL7307681 0.84 SLC6A4 (0.48) SLC6A4HRH3SLC6A9
Oxalic Acid SCHEMBL7317614 0.84 SLC6A4 (0.88) SLC6A4HRH3SLC6A9SLC6A2SLC6A3
SCHEMBL17549671 0.84 SLC6A4 (0.78) SLC6A4HRH3SLC6A9SLC6A2SLC6A3
SCHEMBL685134 0.80 SLC6A4 (0.70) SLC6A4HRH3SLC6A9SLC6A2HTR2A
Oxalic Acid SCHEMBL5142654 0.79 SLC6A9 (0.68) SLC6A4HRH3SLC6A9
SCHEMBL6828424 0.79 SLC6A9 (0.86) SLC6A4HRH3SLC6A9CYP2D6CYP2C19
SCHEMBL21034466 0.79 SLC6A4 (0.73) SLC6A4HRH3SLC6A9SLC6A2SLC6A3
SCHEMBL13080691 0.78 SLC6A9 (0.64) SLC6A4HRH3SLC6A9SLC6A2SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2000021917-A1 PHARMACEUTICAL INTERMEDIATE FOR THE SYNTHESIS OF FLUOXETINE AND A PROCESS FOR THE PREPARATION THEREOF EGIS Gyógyszergyár Rt. (HU) 2000-04-20 WO claimed
WO-2000021917-A1 PHARMACEUTICAL INTERMEDIATE FOR THE SYNTHESIS OF FLUOXETINE AND A PROCESS FOR THE PREPARATION THEREOF EGIS Gyógyszergyár Rt. (HU) 2000-04-20 WO disclosed
WO-2000021917-A1 PHARMACEUTICAL INTERMEDIATE FOR THE SYNTHESIS OF FLUOXETINE AND A PROCESS FOR THE PREPARATION THEREOF EGIS Gyógyszergyár Rt. (HU) 2000-04-20 WO disclosed