Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 7/20 | 0.48 |
| ▸ | MAOB | P27338 | 7/20 | 0.48 |
| ▸ | NPY2R | P49146 | 2/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7366835 | 0.86 | NPY2R (0.49) | LMNAKMT2AACHEBCHEMAOA | |
| Hydrochloric Acid SCHEMBL7292922 | 0.85 | CHRM2 (0.59) | LMNAKMT2ANPY2RCHRM2CHRM3 | |
| SCHEMBL7318685 | 0.84 | GRIN2B (0.49) | LMNAKMT2ANPY2RCHRM3 | |
| Hydrochloric Acid SCHEMBL7307989 | 0.83 | GRIN2B (0.49) | LMNAKMT2ACHRM3 | |
| Hydrochloric Acid SCHEMBL7309309 | 0.82 | KDM1A (0.42) | KMT2AMAOAMAOB | |
| Hydrochloric Acid SCHEMBL7370551 | 0.82 | TSHR (0.40) | MAOAMAOBPARP1 | |
| Hydrochloric Acid SCHEMBL7371616 | 0.80 | HTR1A (0.47) | LMNAPARP1OPRM1 | |
| SCHEMBL9312162 | 0.77 | CYP1A2 (0.45) | — | |
| SCHEMBL7374128 | 0.77 | LMNA (0.58) | LMNAKMT2AACHEBCHEMAOA | |
| SCHEMBL21375648 | 0.75 | SIGMAR1 (0.60) | LMNAKMT2AACHECHRM2CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0255134-B1 | CARBOSTYRIL DERIVATIVES AND SALTS THEREOF, PROCESS FOR PREPARING THEM, AND CARDIOTONIC COMPOSITION CONTAINING SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-03-03 | — | — | EP | claimed |
| EP-0255134-A2 | Carbostyril derivatives and salts thereof, process for preparing them, and cardiotonic composition containing same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-02-03 | — | — | EP | disclosed |