Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.55 |
| ▸ | CCR2 | P41597 | 2/20 | 0.55 |
| ▸ | MAOA | P21397 | 5/20 | 0.51 |
| ▸ | MAOB | P27338 | 5/20 | 0.51 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 3/20 | 0.50 |
| ▸ | BCHE | P06276 | 2/20 | 0.50 |
| ▸ | KIF11 | P52732 | 1/20 | 0.49 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9313388 | 0.87 | PKM (0.50) | LMNAKMT2AROCK2ROCK1CCR2 | |
| SCHEMBL7295865 | 0.83 | ROCK2 (0.60) | LMNAKMT2AROCK2ROCK1LTA4H | |
| SCHEMBL7364603 | 0.79 | CA12 (0.58) | LMNAKIF11KDM1A | |
| SCHEMBL918426 | 0.77 | KDM4E (0.66) | KMT2AROCK2ROCK1CCR2ACHE | |
| SCHEMBL7307710 | 0.77 | LMNA (0.50) | LMNAKMT2AMAOAMAOBACHE | |
| SCHEMBL11040553 | 0.76 | MEN1 (0.62) | LMNAKMT2AKDM4E | |
| SCHEMBL5405680 | 0.75 | ROCK2 (0.62) | ROCK2ROCK1CCR2PDK2ACHE | |
| SCHEMBL7366835 | 0.75 | NPY2R (0.49) | LMNAKMT2AMAOAMAOBACHE | |
| SCHEMBL924357 | 0.74 | ACHE (0.68) | LMNAKMT2AROCK2ROCK1CCR2 | |
| SCHEMBL7296357 | 0.74 | ROCK2 (0.61) | ROCK2ROCK1CCR2PDK2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4886809-A | CARDIOTONIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1989-12-12 | — | — | US | disclosed |
| EP-0255134-A2 | Carbostyril derivatives and salts thereof, process for preparing them, and cardiotonic composition containing same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-02-03 | — | — | EP | disclosed |