Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.77 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.77 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.77 |
| ▸ | DRD3 | P35462 | 1/20 | 0.77 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.77 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.77 |
| ▸ | PTAFR | P25105 | 2/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7309516 | 0.87 | CYP3A4 (0.77) | CYP3A4SLC22A1ABCB11DRD3OPRK1 | |
| Midazolam SCHEMBL29735381 | 0.87 | OPRK1 (1.00) | CYP3A4SLC22A1ABCB11DRD3OPRK1 | |
| Midazolam SCHEMBL29480459 | 0.87 | OPRK1 (1.00) | CYP3A4SLC22A1ABCB11DRD3OPRK1 | |
| Midazolam SCHEMBL35061 | 0.87 | OPRK1 (1.00) | CYP3A4SLC22A1ABCB11DRD3OPRK1 | |
| Midazolam SCHEMBL5783371 | 0.87 | OPRK1 (1.00) | CYP3A4SLC22A1ABCB11DRD3OPRK1 | |
| SCHEMBL13320804 | 0.87 | CYP3A4 (0.77) | CYP3A4SLC22A1ABCB11DRD3OPRK1 | |
| Midazolam SCHEMBL29565146 | 0.87 | OPRK1 (1.00) | CYP3A4SLC22A1ABCB11DRD3OPRK1 | |
| Midazolam SCHEMBL29357425 | 0.87 | OPRK1 (1.00) | CYP3A4SLC22A1ABCB11DRD3OPRK1 | |
| Midazolam SCHEMBL1311204 | 0.86 | OPRK1 (0.98) | CYP3A4SLC22A1ABCB11DRD3OPRK1 | |
| Midazolam SCHEMBL41265 | 0.86 | OPRK1 (0.98) | CYP3A4SLC22A1ABCB11DRD3OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016186559-A1 | METHOD FOR INVESTIGATING BLOOD-BRAIN BARRIER PROPERTIES AND BRAIN METABOLISM USING INSECT BRAINS | QUIXOLABS AB (SE) | 2016-11-24 | — | — | WO | disclosed |
| US-7235656-B2 | Anxiolytic agents with reduced sedative and ataxic effects | WISYS TECHNOLOGY FOUNDATION, INC. (US) | 2007-06-26 | — | — | US | disclosed |
| US-20070054881-A1 | Orally active benzodiazepine derivatives and their salts; anticonvulsants with reduced hypnotic and muscle relaxant side effects; eating and psychological disorders | WISYS TECHNOLOGY FOUNDATION, INC. (US) | 2007-03-08 | — | — | US | disclosed |
| US-4440685-A | MUSCLE RELAXANTS, SEDATIVES, ANTICONVULSANTS | HOFFMANN-LA ROCHE INC. (US) | 1984-04-03 | — | — | US | disclosed |
| US-4425272-A | ANTICONVULSANTS, MUSCLE RELAXANTS, SEDATIVES | HOFFMANN-LA ROCHE INC. (US) | 1984-01-10 | — | — | US | disclosed |
| US-4401597-A | INTERMEDIATES FOR ANTICONVULSANTS, MUSCLE RELAXANTS, SEDATIVE AND ANXIOLYTICS | HOFFMANN-LA ROCHE INC. (US) | 1983-08-30 | — | — | US | disclosed |
| US-4390471-A | INTERMEDIATES FOR IMIDOBENZODIAZEPINE AND ANALOGS | HOFFMANN-LA ROCHE INC. (US) | 1983-06-28 | — | — | US | disclosed |
| US-4377523-A | Imidazodiazepines and processes therefor | HOFFMANN-LA ROCHE INC. (US) | 1983-03-22 | — | — | US | disclosed |
| US-4376075-A | REACTION OF AN AMINODERIVATIVE THEREOF WITH AN ALDEHYDE | HOFFMANN-LA ROCHE INC. (US) | 1983-03-08 | — | — | US | disclosed |
| US-4376074-A | ANTICONVULSANTS, MUSCLE RELAXANTS AND SEDATIVES | HOFFMANN-LA ROCHE INC. (US) | 1983-03-08 | — | — | US | disclosed |
| US-4368157-A | ANTICONVULSANTS, MUSCLE RELAXANTS, TRANQUILIZERS, SEDATIVES | HOFFMANN-LA ROCHE INC. (US) | 1983-01-11 | — | — | US | disclosed |
| US-4368159-A | ANTICONVULSANTS, MUSCLE RELAXANTS, TRANQUILIZERS, SEDATIVES | HOFFMANN-LA ROCHE INC. (US) | 1983-01-11 | — | — | US | disclosed |
| US-4368158-A | ANTICONVULSANTS, MUSCLE RELAXANTS, TRANQUILIZERS, SEDATIVES | HOFFMANN-LA ROCHE INC. (US) | 1983-01-11 | — | — | US | disclosed |
| US-4349477-A | IMIPAZO/1,5-A//1,4/BENZO-, THIENO- OR PYRAZOLODIAZEPINES FROM 2-DIMORPHOLINOPHOSPHONATES OF BENZO-, THIENO- OR PYRAZOLODIAZEPINES | HOFFMANN-LA ROCHE INC. (US) | 1982-09-14 | — | — | US | disclosed |
| US-4349476-A | IMIDAZO/1,5-A//1,4) BENZO-, THIENO-, OR PYRAZOLODIAZEPINES FROM DERIVATIVES OF BENZO-, THIENO- OR PYRAZOLODIAZEPINE | HOFFMANN-LA ROCHE INC. (US) | 1982-09-14 | — | — | US | disclosed |
| US-4349475-A | IMIDAZO/1,5-A//1,4/BENZO-, THIENO-, OR PYRAZOLODIAZEPINES FROM DERIVATIVES OF BENZOTHIENO-OR PYRAZOLODIAZEPINES | HOFFMANN-LA ROCHE INC. (US) | 1982-09-14 | — | — | US | disclosed |
| US-4347365-A | ANTICONVULSANTS, MUSCLE RELAXANTS, SEDATIVES | HOFFMANN-LA ROCHE INC. (US) | 1982-08-31 | — | — | US | disclosed |
| US-4347364-A | INTERMEDIATES THEREFOR | HOFFMANN-LA ROCHE INC. (US) | 1982-08-31 | — | — | US | disclosed |
| US-4307237-A | ANTICONVULSANTS, SEDATIVES, MUSCLE RELAXANTS | HOFFMANN-LA ROCHE INC. (US) | 1981-12-22 | — | — | US | disclosed |
| US-4280957-A | Imidazodiazepines and processes therefor | HOFFMANN-LA ROCHE INC. (US) | 1981-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054881-A1 | Orally active benzodiazepine derivatives and their salts; anticonvulsants with reduced hypnotic and muscle relaxant side effects; eating and psychological disorders | GABRA3, GABRA6, GABRA4 | CYP3A4 103/4885SLC22A1 1402/4885ABCB11 1351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.