Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 5/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | GLS | O94925 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.40 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7319178 | 0.84 | TERT (0.54) | TERTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL7315114 | 0.84 | TERT (0.54) | TERTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL7316154 | 0.84 | TERT (0.52) | TERTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL7313692 | 0.82 | TERT (0.52) | TERTLMNASMN1; SMN2MAPT | |
| SCHEMBL7315148 | 0.78 | AOC3 (0.51) | TERTNPC1RAB9AEPHX2LMNA | |
| SCHEMBL7305741 | 0.77 | MAPK8 (0.49) | TERTRAB9AALDH1A1 | |
| SCHEMBL6326110 | 0.75 | TERT (0.55) | TERTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL7311743 | 0.75 | TERT (0.53) | TERTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL8424358 | 0.69 | EPHX2 (0.66) | NPC1RAB9AEPHX2ALDH1A1LTA4H | |
| SCHEMBL9370053 | 0.67 | EPHX2 (0.71) | NPC1RAB9AGLSEPHX2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0911333-B1 | Pyrazolo[4,3-d]pyrimidine derivatives and pharmaceutical compositions containing them | PFIZER (US) | 2002-04-10 | — | — | EP | disclosed |
| US-6235742-B1 | CARDIOVASCULAR DISORDERS; ANTIALLERGENS | PFIZER INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0911333-A1 | Pyrazolo[4,3-d]pyrimidine derivatives and pharmaceutical compositions containing them | PFIZER INC. (US) | 1999-04-28 | — | — | EP | disclosed |