Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316154 | 0.77 | TERT (0.52) | TERTSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL7308029 | 0.75 | TERT (0.57) | TERTSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL7319178 | 0.74 | TERT (0.54) | TERTSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL7315114 | 0.74 | TERT (0.54) | TERTSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL7311743 | 0.74 | TERT (0.53) | TERTSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL7301563 | 0.74 | TERT (0.61) | TERTSMN1; SMN2LMNAALDH1A1MAPT | |
| SCHEMBL7313692 | 0.72 | TERT (0.52) | TERTSMN1; SMN2LMNAMAPTATM | |
| SCHEMBL5324167 | 0.71 | TERT (0.64) | TERTSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL4037925 | 0.71 | TERT (0.81) | TERTSMN1; SMN2RAB9AALDH1A1L3MBTL1 | |
| SCHEMBL1792 | 0.70 | TERT (0.65) | TERTRAB9ANPC1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6960661-B2 | [7-(3-chloro-4-methoxybenzlamino)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-ylmethoxy]acetic acid, synthesis thereof and intermediates used therein | MERCK PATENT GMBH (DE) | 2005-11-01 | — | — | US | claimed |
| US-20040053945-A1 | Process for the preparation of a pyrazolo[4,3-d]pyrimidine derivative | MERCK PATENT GMBH (DE) | 2004-03-18 | — | — | US | claimed |
| EP-1358189-A1 | PROCESS FOR THE PREPARATION OF A PYRAZOLO 4,3-D]PYRIMIDINE DERIVATIVE | MERCK PATENT GmbH (DE) | 2003-11-05 | — | — | EP | claimed |
| WO-2002059126-A1 | PROCESS FOR THE PREPARATION OF A PYRAZOLO[4,3-D]PYRIMIDINE DERIVATIVE | MERCK PATENT GMBH (DE) | 2002-08-01 | — | — | WO | claimed |
| US-6960661-B2 | [7-(3-chloro-4-methoxybenzlamino)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-ylmethoxy]acetic acid, synthesis thereof and intermediates used therein | MERCK PATENT GMBH (DE) | 2005-11-01 | — | — | US | disclosed |
| US-20040053945-A1 | Process for the preparation of a pyrazolo[4,3-d]pyrimidine derivative | MERCK PATENT GMBH (DE) | 2004-03-18 | — | — | US | disclosed |
| EP-1358189-A1 | PROCESS FOR THE PREPARATION OF A PYRAZOLO 4,3-D]PYRIMIDINE DERIVATIVE | MERCK PATENT GmbH (DE) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002059126-A1 | PROCESS FOR THE PREPARATION OF A PYRAZOLO[4,3-D]PYRIMIDINE DERIVATIVE | MERCK PATENT GMBH (DE) | 2002-08-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040053945-A1 | Process for the preparation of a pyrazolo[4,3-d]pyrimidine derivative | HPD, DDC, KMO | TERT 2859/4885SMN1; SMN2 3289/4885RAB9A 3368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.