Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 6/20 | 0.38 |
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PDE5A | O76074 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7319178 | 0.86 | TERT (0.54) | TERTSMN1; SMN2LMNANLRP3RAB9A | |
| SCHEMBL7315114 | 0.86 | TERT (0.54) | TERTSMN1; SMN2LMNANLRP3RAB9A | |
| SCHEMBL7308029 | 0.84 | TERT (0.57) | TERTSMN1; SMN2LMNARAB9ANPC1 | |
| SCHEMBL7313692 | 0.83 | TERT (0.52) | TERTSMN1; SMN2LMNANLRP3MAPK8 | |
| SCHEMBL7315148 | 0.79 | AOC3 (0.51) | TERTSMN1; SMN2LMNARAB9ANPC1 | |
| SCHEMBL7305741 | 0.78 | MAPK8 (0.49) | TERTRAB9AMAPK8ALDH1A1 | |
| SCHEMBL6326110 | 0.77 | TERT (0.55) | TERTSMN1; SMN2LMNARAB9ANPC1 | |
| SCHEMBL7311743 | 0.77 | TERT (0.53) | TERTSMN1; SMN2LMNARAB9ANPC1 | |
| SCHEMBL7301563 | 0.76 | TERT (0.61) | TERTSMN1; SMN2LMNAMAPK8POLB | |
| SCHEMBL1792 | 0.71 | TERT (0.65) | TERTLMNARAB9ANPC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0911333-B1 | Pyrazolo[4,3-d]pyrimidine derivatives and pharmaceutical compositions containing them | PFIZER (US) | 2002-04-10 | — | — | EP | disclosed |
| US-6235742-B1 | CARDIOVASCULAR DISORDERS; ANTIALLERGENS | PFIZER INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0911333-A1 | Pyrazolo[4,3-d]pyrimidine derivatives and pharmaceutical compositions containing them | PFIZER INC. (US) | 1999-04-28 | — | — | EP | disclosed |