Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7315114 | 0.91 | TERT (0.54) | TERTSMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL7311743 | 0.90 | TERT (0.53) | TERTSMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL7316154 | 0.86 | TERT (0.52) | TERTSMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL7313692 | 0.86 | TERT (0.52) | TERTSMN1; SMN2LMNAPOLBNLRP3 | |
| SCHEMBL7308029 | 0.84 | TERT (0.57) | TERTSMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL7315148 | 0.82 | AOC3 (0.51) | TERTSMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL7305741 | 0.81 | MAPK8 (0.49) | TERTRAB9AALDH1A1 | |
| SCHEMBL7301563 | 0.77 | TERT (0.61) | TERTSMN1; SMN2LMNAKMT2AALDH1A1 | |
| SCHEMBL6326110 | 0.74 | TERT (0.55) | TERTSMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL7623232 | 0.70 | MEN1 (0.51) | SMN1; SMN2LMNANPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0911333-B1 | Pyrazolo[4,3-d]pyrimidine derivatives and pharmaceutical compositions containing them | PFIZER (US) | 2002-04-10 | — | — | EP | disclosed |
| US-6235742-B1 | CARDIOVASCULAR DISORDERS; ANTIALLERGENS | PFIZER INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0911333-A1 | Pyrazolo[4,3-d]pyrimidine derivatives and pharmaceutical compositions containing them | PFIZER INC. (US) | 1999-04-28 | — | — | EP | disclosed |