Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.49 |
| ▸ | TERT | O14746 | 5/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7315114 | 0.81 | TERT (0.54) | TERTALDH1A1MAPK1RAB9A | |
| SCHEMBL7319178 | 0.81 | TERT (0.54) | TERTALDH1A1RAB9A | |
| SCHEMBL7315148 | 0.78 | AOC3 (0.51) | TERTADORA2ARAB9A | |
| SCHEMBL7316154 | 0.78 | TERT (0.52) | MAPK8TERTALDH1A1RAB9A | |
| SCHEMBL7313692 | 0.78 | TERT (0.52) | MAPK8TERTADORA2BADORA1HDAC1 | |
| SCHEMBL7308029 | 0.77 | TERT (0.57) | TERTALDH1A1RAB9A | |
| SCHEMBL7301563 | 0.73 | TERT (0.61) | MAPK8TERTALDH1A1MAPK1 | |
| SCHEMBL13359258 | 0.70 | HPGD (0.64) | MAPK8HDAC1HDAC8ALDH1A1MAPK1 | |
| SCHEMBL6326110 | 0.69 | TERT (0.55) | TERTALDH1A1RAB9A | |
| SCHEMBL8636561 | 0.68 | MAPK8 (0.67) | MAPK8HDAC1HDAC8ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0911333-B1 | Pyrazolo[4,3-d]pyrimidine derivatives and pharmaceutical compositions containing them | PFIZER (US) | 2002-04-10 | — | — | EP | disclosed |
| US-6235742-B1 | CARDIOVASCULAR DISORDERS; ANTIALLERGENS | PFIZER INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0911333-A1 | Pyrazolo[4,3-d]pyrimidine derivatives and pharmaceutical compositions containing them | PFIZER INC. (US) | 1999-04-28 | — | — | EP | disclosed |