Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TUBB | P07437 | 1/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2121837 | 0.92 | HCRTR1 (0.35) | TLR7HCRTR1HCRTR2ALDH1A1MAPK1 | |
| SCHEMBL7298547 | 0.88 | ALDH1A1 (0.40) | ALDH1A1MAPK1LMNACYP1A2CYP2D6 | |
| SCHEMBL833 | 0.81 | GPR84 (0.37) | GPR84NPC1RAB9AALDH1A1MAPK1 | |
| SCHEMBL7883601 | 0.81 | PDE2A (0.33) | NPC1RAB9AMAPK1MAPT | |
| SCHEMBL27334926 | 0.80 | GPR84 (0.41) | GPR84NPC1RAB9AALDH1A1MAPK1 | |
| SCHEMBL7303318 | 0.80 | NPSR1 (0.41) | GPR84NPC1RAB9AALDH1A1MAPK1 | |
| SCHEMBL2123507 | 0.79 | LMNA (0.41) | GPR84NPC1RAB9AALDH1A1MAPK1 | |
| SCHEMBL27446651 | 0.79 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL987234 | 0.79 | ALDH1A1 (0.42) | ALDH1A1CYP1A2CYP2D6TSHR | |
| SCHEMBL9873189 | 0.78 | GPR84 (0.37) | TLR8TLR7GPR84NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1101384-C | Process for preparing 1-biphenylmethylimidazole derivatives | SANKYO CO (JP) | 2003-02-12 | — | — | CN | disclosed |
| EP-0503785-B1 | 1-Biphenylimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 2001-04-25 | — | — | EP | disclosed |
| CN-1045770-C | Process for preparing 1-biphenylmethylimidazole derivatives | SANKYO CO (JP) | 1999-10-20 | — | — | CN | disclosed |
| CN-1189490-A | Process for preparing 1-biphenylmethylimidazole derivatives | SANKYO CO (JP) | 1998-08-05 | — | — | CN | disclosed |
| US-5646171-A | HYPOTENSIVE AGENTS | SANKYO COMPANY, LIMITED (JP) | 1997-07-08 | — | — | US | disclosed |
| US-5616599-A | HYPOTENSIVE AGENTS FOR CARDIOVASCULAR DISORDER | SANKYO COMPANY, LIMITED (JP) | 1997-04-01 | — | — | US | disclosed |
| CN-1065063-A | 1-Biphenylmethylimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 1992-10-07 | — | — | CN | disclosed |
| EP-0503785-A1 | 1-Biphenylimidazole derivatives, their preparation and their therapeutic use | Sankyo Company Limited (JP) | 1992-09-16 | — | — | EP | disclosed |