Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7423269 | 0.87 | ALDH1A1 (0.43) | ALDH1A1MAPK1LMNACYP1A2 | |
| SCHEMBL7303318 | 0.83 | NPSR1 (0.41) | GPR84NPC1RAB9AALDH1A1MAPK1 | |
| SCHEMBL27334926 | 0.83 | GPR84 (0.41) | GPR84NPC1RAB9AALDH1A1MAPK1 | |
| SCHEMBL3038066 | 0.83 | PARP1 (0.41) | GPR84ALDH1A1MAPK1PARP1 | |
| SCHEMBL9873189 | 0.82 | GPR84 (0.37) | GPR84NPC1RAB9AALDH1A1MAPK1 | |
| SCHEMBL27542325 | 0.82 | GPR84 (0.37) | GPR84NPC1RAB9AALDH1A1MAPK1 | |
| SCHEMBL7308356 | 0.81 | TLR8 (0.36) | GPR84NPC1RAB9AALDH1A1MAPK1 | |
| SCHEMBL5036239 | 0.81 | L3MBTL1 (0.40) | GPR84NPC1RAB9AALDH1A1LMNA | |
| SCHEMBL27336186 | 0.81 | GPR84 (0.36) | GPR84NPC1RAB9AALDH1A1MAPK1 | |
| SCHEMBL8653487 | 0.79 | GPR84 (0.35) | GPR84NPC1RAB9AALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0649424-B1 | DIOXCYCLOBUTENE DERIVATIVES AS ANGIOTENSIN II ANTAGONISTS | KNOLL AG (DE) | 1998-10-07 | — | — | EP | disclosed |
| EP-0733366-B1 | Pharmaceutical compositions comprising angiotensin II receptor blocking imidazoles and diuretics | DU PONT (US) | 1998-04-01 | — | — | EP | disclosed |
| US-5627191-A | Therapeutic agents | THE BOOTS COMPANY PLC (GB) | 1997-05-06 | — | — | US | disclosed |
| CN-1034662-C | Process for preparing tetrazde devivatives and their use | CHEM PHARM FORSCH GMBH (AT) | 1997-04-23 | — | — | CN | disclosed |
| EP-0324377-B1 | Angiotensin II receptor blocking imidazoles and combinations thereof with diuretics and NSaids | DU PONT (US) | 1997-04-16 | — | — | EP | disclosed |
| EP-0733366-A2 | Pharmaceutical compositions comprising angiotensin II receptor blocking imidazoles and diuretics | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1996-09-25 | — | — | EP | disclosed |
| US-5387684-A | For treatment and prophylaxis of angiotensin II-mediated diseases such as circulatory diseases of hypertension and heart failure | THE GREEN CROSS CORPORATION (JP) | 1995-02-07 | — | — | US | disclosed |
| EP-0602246-A1 | ISOINDAZOLE COMPOUND | THE GREEN CROSS CORPORATION (JP) | 1994-06-22 | — | — | EP | disclosed |
| WO-1994001436-A1 | DIOXCYCLOBUTENE DERIVATIVES AS ANGIOTENSIN II ANTAGONISTS | THE BOOTS COMPANY PLC (GB) | 1994-01-20 | — | — | WO | disclosed |
| US-5236928-A | Hypotensive | MERCK & CO., INC. (US) | 1993-08-17 | — | — | US | disclosed |
| US-5155118-A | Administering angiotensin inhibitor | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-10-13 | — | — | US | disclosed |
| US-5153197-A | Treatment of hypertension with angiotensin II blocking imidazoles | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-10-06 | — | — | US | disclosed |
| EP-0505098-A1 | Imidazole derivatives bearing acidic functional groups as angiotensin II antagonists | MERCK & CO. INC. (US) | 1992-09-23 | — | — | EP | disclosed |
| CN-1063689-A | The preparation method of new terazole derivatives and application thereof | CHEM PHARM FORSCH GMBH (AT) | 1992-08-19 | — | — | CN | disclosed |
| US-5138069-A | Treating hypertension and congestive heart failure | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-08-11 | — | — | US | disclosed |
| US-5128355-A | Hypotensive | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-07-07 | — | — | US | disclosed |
| EP-0324377-A2 | Angiotensin II receptor blocking imidazoles and combinations thereof with diuretics and NSaids | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-07-19 | — | — | EP | disclosed |
| WO-1989006233-A1 | ANGIOTENSIN II RECEPTOR BLOCKING IMIDAZOLES AND COMBINATIONS THEREOF WITH DIURETICS AND NSAIDS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-07-13 | — | — | WO | disclosed |