Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 4/20 | 0.44 |
| ▸ | MMP3 | P08254 | 3/20 | 0.44 |
| ▸ | MMP2 | P08253 | 3/20 | 0.44 |
| ▸ | MMP8 | P22894 | 2/20 | 0.44 |
| ▸ | MMP13 | P45452 | 2/20 | 0.44 |
| ▸ | MMP9 | P14780 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 2/20 | 0.38 |
| ▸ | CTSB | P07858 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7308423 | 1.00 | MMP1 (0.44) | MMP1MMP3MMP2MMP8MMP13 | |
| SCHEMBL7280170 | 0.84 | MMP2 (0.60) | MMP1MMP3MMP2MMP8MMP13 | |
| SCHEMBL7280160 | 0.84 | MMP2 (0.60) | MMP1MMP3MMP2MMP8MMP13 | |
| SCHEMBL7373620 | 0.72 | MAPK1 (0.49) | MMP1MMP3MMP2MMP8MMP13 | |
| SCHEMBL7373619 | 0.72 | MAPK1 (0.49) | MMP1MMP3MMP2MMP8MMP13 | |
| SCHEMBL7373763 | 0.72 | MAPK1 (0.49) | MMP1MMP3MMP2MMP8MMP13 | |
| SCHEMBL8601030 | 0.69 | ECE1 (0.49) | MMP1RAB9ACTSLCTSBCTSK | |
| SCHEMBL9714088 | 0.69 | CTSK (0.39) | MMP1MMP2MMP9RAB9ACTSL | |
| SCHEMBL7375195 | 0.68 | MMP1 (0.46) | MMP1MMP3MMP2MMP8MMP13 | |
| SCHEMBL7371909 | 0.68 | MMP1 (0.46) | MMP1MMP3MMP2MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0574758-B1 | Hydroxamic acid derivatives as collagenase inhibitors | HOFFMANN LA ROCHE (CH) | 1998-09-09 | — | — | EP | disclosed |
| US-5318964-A | Collangenase inhibitors; antiarthritic and -tumor agents; rheumatic diseases; osteoarthritis; atherosclerosis; multiple sclerosis | HOFFMANN-LA ROCHE INC. (US) | 1994-06-07 | — | — | US | disclosed |
| EP-0574758-A1 | Hydroxamic acid derivatives as collagenase inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1993-12-22 | — | — | EP | disclosed |