Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 15/20 | 0.41 |
| ▸ | CCKAR | P32238 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | NOTCH1 | P46531 | 2/20 | 0.37 |
| ▸ | NOTCH3 | Q9UM47 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7312531 | 0.95 | CCKBR (0.40) | CCKBRCCKARKCNH2NOTCH1NOTCH3 | |
| SCHEMBL7312856 | 0.86 | CCKBR (0.42) | CCKBRCCKARNOTCH1NOTCH3MAPT | |
| SCHEMBL8863378 | 0.84 | CCKBR (0.55) | CCKBRCCKARKCNH2NOTCH1NOTCH3 | |
| SCHEMBL7626581 | 0.84 | CCKBR (0.55) | CCKBRCCKARKCNH2NOTCH1NOTCH3 | |
| SCHEMBL9867211 | 0.81 | CCKBR (0.56) | CCKBRCCKARNOTCH1NOTCH3 | |
| SCHEMBL7304401 | 0.80 | CCKBR (0.45) | CCKBRCCKARMAPTKMT2A | |
| SCHEMBL9865708 | 0.80 | CCKBR (0.57) | CCKBRCCKAR | |
| SCHEMBL9368599 | 0.76 | CCKBR (0.57) | CCKBRKCNH2 | |
| SCHEMBL7304003 | 0.75 | GABRP (0.60) | CCKBRCCKARNOTCH1NOTCH3ALDH1A1 | |
| SCHEMBL9288758 | 0.75 | CCKBR (0.39) | CCKBRKCNH2NOTCH1NOTCH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5798353-A | Polysubstituted 3-acylamino-5-phenyl-1,4-benzodiazepin-2-one derivatives, process for their preparation and the pharmaceutical compositions containing them | SANOFI (FR) | 1998-08-25 | — | — | US | disclosed |
| US-5719143-A | Polysubstituted 3-acylamino-5-phenyl-1, 4-benzodiazepin-2-one derivatives, process for their preparation and the pharmaceutical compositions containing them | SANOFI (FR) | 1998-02-17 | — | — | US | disclosed |
| EP-0667344-A1 | 3-acylamino-5-(polysubstituted phenyl)-1,4-benzodiazepin-2-ones useful as CCK-receptor agonists | SANOFI (FR) | 1995-08-16 | — | — | EP | disclosed |