Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 13/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 7/20 | 0.50 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.50 |
| ▸ | HTR1A | P08908 | 4/20 | 0.48 |
| ▸ | TOP2A | P11388 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7307680 | 0.87 | ADRB2 (0.55) | KDM4EALDH1A1KMT2AADRB2ADRB1 | |
| SCHEMBL7312955 | 0.84 | ADRB2 (0.57) | KDM4EALDH1A1KMT2AADRB2ADRB1 | |
| SCHEMBL7308956 | 0.82 | ADRB2 (0.50) | KDM4EALDH1A1KMT2AADRB2ADRB1 | |
| SCHEMBL7315445 | 0.82 | ADRB3 (0.56) | KDM4EALDH1A1KMT2AADRB2ADRB1 | |
| SCHEMBL7302638 | 0.82 | ALDH1A1 (0.60) | KDM4EALDH1A1KMT2AADRB2ADRB1 | |
| SCHEMBL7309300 | 0.81 | KDM4E (0.48) | KDM4EALDH1A1KMT2AADRB2ADRB1 | |
| SCHEMBL7311030 | 0.81 | ADRB3 (0.55) | KDM4EALDH1A1KMT2AADRB2ADRB1 | |
| SCHEMBL7314435 | 0.81 | ADRB3 (0.55) | KDM4EALDH1A1KMT2AADRB2ADRB1 | |
| SCHEMBL7309456 | 0.81 | ADRB3 (0.60) | ALDH1A1KMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL7319624 | 0.81 | KMT2A (0.56) | KDM4EALDH1A1KMT2AADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4258062-A | ISOPRENALINE ANTAGONISTS EFFECTING HEART RATE AND BLOOD PRESSURE | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-03-24 | — | — | US | disclosed |
| US-4171370-A | Phenoxy-amino-propanols | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1979-10-16 | — | — | US | disclosed |