Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 3/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | SNCA | P37840 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7309205 | 0.82 | MMP2 (0.51) | PDE4APDE4BPDE4CPDE4DSNCA | |
| SCHEMBL7303121 | 0.82 | MMP2 (0.60) | PDE4APDE4BPDE4CPDE4DMMP1 | |
| SCHEMBL7312050 | 0.79 | PDE4A (0.69) | NFE2L2TRPA1PDE4APDE4BPDE4C | |
| SCHEMBL7309376 | 0.78 | CYP1A1 (0.49) | NFE2L2TRPA1CAPN1PDE4APDE4B | |
| SCHEMBL7303135 | 0.77 | MME (0.47) | MMP1MMP2MMELTA4HANPEP | |
| SCHEMBL7308706 | 0.77 | MMP1 (0.46) | PDE4APDE4BPDE4CPDE4DMMP1 | |
| SCHEMBL7303711 | 0.75 | MMP2 (0.51) | PDE4APDE4BPDE4CPDE4DMMP1 | |
| SCHEMBL7299652 | 0.74 | MME (0.44) | MMP1MMELTA4HANPEPECE1 | |
| SCHEMBL7308918 | 0.72 | FCER2 (0.48) | PDE4APDE4BPDE4CPDE4DMMP1 | |
| SCHEMBL27477944 | 0.72 | MME (0.42) | MMP1MMELTA4HANPEPECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |